Protein Alignment CG17121 and HSD17B13

DIOPT Version :10

• Sequence 1: NP_651114.1
• Gene: CG17121 / 42721
• FlyBaseID: FBgn0039043
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: NP_835236.2
• Gene: HSD17B13 / 345275
• HGNCID: 18685
• Length: 300
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 86/289 - (29%)
• Similarity: 149/289 - (51%)
• Gaps: 18/289 - (6%)

  Fly    55 LKVIVFLLLLPLVLLAVFLKHLLDYLFALGLKEKDVSGKVALVTGGGSGLGREICLELARRGCKL 119
            :.:|:.:|||.:.::..:|:.|:.  |.:..:.|.|:|::.|:||.|.|:||:...|.|:|...|
Human     1 MNIILEILLLLITIIYSYLESLVK--FFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSIL 63

  Fly   120 AVVDVNSKGCYETVELLSKIPRCVAKAYKNDVSSPRELQLMAAKVEKELGPVDILVNNASLMPMT 184
            .:.|:|.:|..||.....|: ...|.||..|.|:..|:.....:|:||:|.|.|:||||..:...
Human    64 VLWDINKRGVEETAAECRKL-GVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPA 127

  Fly   185 STPSLKSDEIDTILQLNLGSYIMTTKEFLPKMINRKSGHLVAVNALAGLVPLPGAGIYTATKYGI 249
            ...|.|.:||....::|:..:...||..||.|:.|..||:|.|.::.|...:|....|.::|:..
Human   128 DLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAA 192

  Fly   250 EGFMESLRAELRLSDCDYVRTTVANAYLMRTSGDLPLLSDAGIAKS-----YPGLPTPYVAEKIV 309
            .||...|.:||:...    :|.:      :||...|:..:.|..|:     :|.|.|..|...::
Human   193 VGFHRGLTSELQALG----KTGI------KTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLI 247

  Fly   310 KGVLLNERMVYVPKIFALSVWLLRLLPTK 338
            .|:|.|::|::||....:.:.|.:.||.:
Human   248 DGILTNKKMIFVPSYINIFLRLQKFLPER 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17121	NP_651114.1	Rossmann-fold NAD(P)(+)-binding proteins	94..338	CDD:473865	76/248 (31%)
HSD17B13	NP_835236.2	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	76/250 (30%)