Protein Alignment CG17121 and HSD17B2

DIOPT Version :10

• Sequence 1: NP_651114.1
• Gene: CG17121 / 42721
• FlyBaseID: FBgn0039043
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: NP_002144.1
• Gene: HSD17B2 / 3294
• HGNCID: 5211
• Length: 387
• Species: Homo sapiens
• Alignment Length: 214
• Identity: 58/214 - (27%)
• Similarity: 95/214 - (44%)
• Gaps: 15/214 - (7%)

  Fly    55 LKVIVFLLLLP---LVLLAVFLKHLLDYLFALGLKEKDVSGKVALVTGGGSGLGREICLELARRG 116
            |..:..|:|.|   |:|.:|  ...|.|.:..|.:...|..|..|||||..|||..:|..|...|
Human    44 LCAVCLLILSPFWGLILFSV--SCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELG 106

  Fly   117 CKL--AVVDVNSKGCYETVELLSKIPRCVAKAYKNDVSSPRELQLMAAKVEKELGPVDI--LVNN 177
            ..:  .|::.|..|..|.....|  ||  ....:.|::.|.:::...:||...|....:  ::||
Human   107 FTVFAGVLNENGPGAEELRRTCS--PR--LSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINN 167

  Fly   178 ASLMPM-TSTPSLKSDEIDTILQLNLGSYIMTTKEFLPKMINRKSGHLVAVNALAGLVPLPGAGI 241
            |.::.. |....|...:....:.:|....:..||.||| ::.:..|.||.|:::.|..|:.....
Human   168 AGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLP-LLRKSKGRLVNVSSMGGGAPMERLAS 231

  Fly   242 YTATKYGIEGFMESLRAEL 260
            |.::|..:..|...:|.||
Human   232 YGSSKAAVTMFSSVMRLEL 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17121	NP_651114.1	Rossmann-fold NAD(P)(+)-binding proteins	94..338	CDD:473865	46/172 (27%)
HSD17B2	NP_002144.1	type2_17beta_HSD-like_SDR_c	83..362	CDD:187665	47/173 (27%)