Protein Alignment CG17121 and Hsd17b3

DIOPT Version :10

• Sequence 1: NP_651114.1
• Gene: CG17121 / 42721
• FlyBaseID: FBgn0039043
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: NP_032317.2
• Gene: Hsd17b3 / 15487
• MGIID: 107177
• Length: 305
• Species: Mus musculus
• Alignment Length: 331
• Identity: 76/331 - (22%)
• Similarity: 131/331 - (39%)
• Gaps: 88/331 - (26%)

  Fly    59 VFLLLLPLVLLAVFLKHL-LDYLFALGLKEKDVSGKVALVTGGGSGLGREICLELARRGCKLAVV 122
            :|:.|:.||....|.:|| |.:..||........|:.|::||.|.|:|:....||||.|..:.::
Mouse    10 LFVGLVCLVKCMRFSQHLFLRFCKALPSSFLRSMGQWAVITGAGDGIGKAYSFELARHGLNVVLI 74

  Fly   123 DVNSKGCYETVELLSKIPRCVAKAYKNDVSSPRELQLMAAKVEKELG------------------ 169
            .       .|:|                     :||.:|.::|:..|
Mouse    75 S-------RTLE---------------------KLQTIAEEIERTTGSCVKIVQADFTREDIYDH 111

  Fly   170 --------PVDILVNNASLMPMTSTPS---LKSDEIDTILQLNLGSYIMTTKEFLPKMINRKSGH 223
                    .:.|||||..::| :..||   ..|.|...::..|:.|.:..|:..|..|.:|:.|.
Mouse   112 IKEHLEGLEIGILVNNVGMLP-SFFPSHFLSTSGESQNLIHCNITSVVKMTQLVLKHMESRRKGL 175

  Fly   224 LVAVNALAGLVPLPGAGIYTATKYGIEGFMESLRAELRLSD------CDYVRTTVANAYLMRTSG 282
            ::.:::.|.|.|.|...:|:|:|..:..|.::|..|.|...      ..|..:|....||   :.
Mouse   176 ILNISSGAALRPWPLYSLYSASKAFVYTFSKALSVEYRDKGIIIQVLTPYSISTPMTKYL---NN 237

  Fly   283 DLPLLSDAGIAKSYPGLPTPYV----------AEKIVKGVLLNERMVYVPKIFALSVWLLRLLPT 337
            .:...:|..:.:|     ..||          |.:|: .::||.    :|.....|....|.|.|
Mouse   238 KMTKTADEFVKES-----LKYVTIGAESCGCLAHEII-AIILNR----IPSRIFYSSTAQRFLLT 292

  Fly   338 KWQDYM 343
            ::.||:
Mouse   293 RYSDYL 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17121	NP_651114.1	Rossmann-fold NAD(P)(+)-binding proteins	94..338	CDD:473865	62/288 (22%)
Hsd17b3	NP_032317.2	17beta-HSD1_like_SDR_c	44..280	CDD:187614	60/277 (22%)