Protein Alignment CG17121 and RDH12

DIOPT Version :10

• Sequence 1: NP_651114.1
• Gene: CG17121 / 42721
• FlyBaseID: FBgn0039043
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: NP_689656.2
• Gene: RDH12 / 145226
• HGNCID: 19977
• Length: 316
• Species: Homo sapiens
• Alignment Length: 272
• Identity: 70/272 - (25%)
• Similarity: 112/272 - (41%)
• Gaps: 53/272 - (19%)

  Fly    62 LLLPLVLLAVFLKHL------LDYLFALGLKEKDVS--GKVALVTGGGSGLGREICLELARRGCK 118
            :|:.|.||..|...|      :...||.|:...:|.  |||.::||..:|:|:|...|||.||.:
Human     1 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGAR 65

  Fly   119 --LAVVDVNSKGCYETVELLSKIPRCVAKAYKNDVSSPRELQLMAAKVEKELGPVDILVNNASLM 181
              :|..|| .||.....|:............|.|:|..:.::..|.....|...:.||:|||.:|
Human    66 VYIACRDV-LKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVM 129

  Fly   182 --PMTSTPSLKSDEIDTILQLN-LGSYIMTTKEFLPKMINRKSGHLVAVNALA---GLVPLPGAG 240
              |.:.|    :|..:|.|.:| ||.:::|.. .|.::.......:|.|:::|   |.:|
Human   130 MCPYSKT----ADGFETHLGVNHLGHFLLTYL-LLERLKVSAPARVVNVSSVAHHIGKIP----- 184

  Fly   241 IYTATKYGIEGFMESLRAELRLS-DCDYVRTTVANAYLMRTSGDLPLLSDAGIAKSYPGLPTPYV 304
                        ...|::|.|.| ...|..:.:||....|.           :||...|  |...
Human   185 ------------FHDLQSEKRYSRGFAYCHSKLANVLFTRE-----------LAKRLQG--TGVT 224

  Fly   305 AEKIVKGVLLNE 316
            ...:..||:.:|
Human   225 TYAVHPGVVRSE 236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17121	NP_651114.1	Rossmann-fold NAD(P)(+)-binding proteins	94..338	CDD:473865	58/232 (25%)
RDH12	NP_689656.2	retinol-DH_like_SDR_c	39..307	CDD:212495	60/234 (26%)