Protein Alignment CG17121 and Hsd17b3

DIOPT Version :10

• Sequence 1: NP_651114.1
• Gene: CG17121 / 42721
• FlyBaseID: FBgn0039043
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: NP_446459.1
• Gene: Hsd17b3 / 117182
• RGDID: 621805
• Length: 306
• Species: Rattus norvegicus
• Alignment Length: 331
• Identity: 80/331 - (24%)
• Similarity: 142/331 - (42%)
• Gaps: 75/331 - (22%)

  Fly    53 FNLKVIVFLLLLPLVLLAVFLKHL-LDYLFALGLKEKDVSGKVALVTGGGSGLGREICLELARRG 116
            |.|.|.:.:.|:.||....|.::| |.:..||........|:.|::||.|.|:|:....||||.|
  Rat     4 FLLSVGLLVCLVCLVKCVRFSRYLFLSFCKALPGSFLRSMGQWAVITGAGDGIGKAYSFELARHG 68

  Fly   117 CKLAVVDVNSKGCYETVELL------------SKIPRCVAKAYKNDVSSPRELQLMAAKVEKELG 169
            ..:.::.       .|:|.|            |::....|...:.|:....|.||...    |:|
  Rat    69 LNVVLIS-------RTLEKLQVISEEIERTTGSRVKVVQADFTREDIYDHIEEQLKGL----EIG 122

  Fly   170 PVDILVNNASLMPMTSTPS---LKSDEIDTILQLNLGSYIMTTKEFLPKMINRKSGHLVAVNALA 231
               :||||..::| ...||   ..|.|..:::..|:.|.:..|:..|..|.:|:.|.::.:::..
  Rat   123 ---VLVNNVGMLP-NLLPSHFLSTSGESQSVIHCNITSVVKMTQLVLKHMESRRRGLILNISSGV 183

  Fly   232 GLVPLPGAGIYTATKYGIEGFMESLRAELRLSDCDYVRTTVANAYLMRTSGDLPL---LSDAGIA 293
            |:.|.|...:|:|:|..:..|.::|..|.|...   :...|...|.:.|    |:   |:.:.:.
  Rat   184 GVRPWPLYSLYSASKAFVCTFSKALNVEYRDKG---IIIQVLTPYSVST----PMTKYLNTSRVT 241

  Fly   294 KSYPGLPTPYVAEKIVKGVLLNERMVYVP-----------KIFALSVWLLRLLPTK------WQD 341
            |:         |::.||     |.:.||.           :|.|:   :|.|:|::      .|.
  Rat   242 KT---------ADEFVK-----ESLKYVTIGAETCGCLAHEILAI---ILNLIPSRIFYSSTTQR 289

  Fly   342 YMLLRF 347
            ::|.:|
  Rat   290 FLLKQF 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17121	NP_651114.1	Rossmann-fold NAD(P)(+)-binding proteins	94..338	CDD:473865	65/272 (24%)
Hsd17b3	NP_446459.1	17beta-HSD1_like_SDR_c	44..281	CDD:187614	66/275 (24%)