Protein Alignment CG17121 and DHRS9

DIOPT Version :10

• Sequence 1: NP_651114.1
• Gene: CG17121 / 42721
• FlyBaseID: FBgn0039043
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: NP_001276692.1
• Gene: DHRS9 / 10170
• HGNCID: 16888
• Length: 379
• Species: Homo sapiens
• Alignment Length: 359
• Identity: 80/359 - (22%)
• Similarity: 137/359 - (38%)
• Gaps: 109/359 - (30%)

  Fly    63 LLPLVLLAVFLKH--------LLDYLFALG--------LKEKDVSGKVALVTGGGSGLGREICLE 111
            ||.|....|:|.|        :|..|...|        ||.:|::.|...:||..||.|
Human    44 LLVLYKKGVYLSHTGGKMLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFG------ 102

  Fly   112 LARRGCKLAVVDVNSKGCYETVELLSKIPRCVAKAYKN--------DVSSPRELQLMAAKVEKEL 168
                  .||....:.||.:.....|::......||..:        ||:.|..::..|..|:.::
Human   103 ------NLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQV 161

  Fly   169 GPVDI--LVNNASLMPMTSTPS--LKSDEIDTILQLNLGSYIMTTKEFLPKMINRKSGHLVAVNA 229
            |...:  |:|||. :|....|:  |..::....:::||...|..|...|| ::.:..|.::.|::
Human   162 GEKGLWGLINNAG-VPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSS 224

  Fly   230 LAGLVPLPGAGIYTATKYGIEGFMESLRAELR-----------------LSD------------- 264
            :.|.:.:.|.| ||.:||.:|||.:|||.:::                 |:|
Human   225 VGGRLAIVGGG-YTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWE 288

  Fly   265 --CDYVRTTVANAYLMRTSGDL------------PLLS--DAGIAKSYPGLPTPYVAEKIVKGVL 313
              ...::......|:.::...|            |::.  |..:...:|  .|.|.|.|..
Human   289 QLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFP--KTHYAAGKDA---- 347

  Fly   314 LNERMVYVPKIFALSVWL-LRLLPTKWQDYMLLR 346
                     |||    |: |..:|...||::||:
Human   348 ---------KIF----WIPLSHMPAALQDFLLLK 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17121	NP_651114.1	Rossmann-fold NAD(P)(+)-binding proteins	94..338	CDD:473865	63/302 (21%)
DHRS9	NP_001276692.1	type2_17beta_HSD-like_SDR_c	90..366	CDD:187665	66/309 (21%)