DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13833 and HSD17B11

DIOPT Version :9

Sequence 1:	NP_651111.1	Gene:	CG13833 / 42718	FlyBaseID:	FBgn0039040	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_057329.3	Gene:	HSD17B11 / 51170	HGNCID:	22960	Length:	300	Species:	Homo sapiens

Alignment Length:	293	Identity:	88/293 - (30%)
Similarity:	148/293 - (50%)	Gaps:	13/293 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LIGLAAITPLLILVALLGRLIAKLCWCSAPKSIAGEVAVVTGAGHGLGRAISLELAKKGCHIAVV 82
            |:.:..:.||||:.:|  ....||......||:.||:.::||||||:||..:.|.||....:.:.
Human     4 LLDILLLLPLLIVCSL--ESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLW 66

  Fly    83 DINVSGAEDTVKQIQDIYKVRAKAYKANVTNYDDLVELNSKVVEEMGPVTVLVNNAGVMMHRNMF 147
            |||..|.|:|..:.:.: ..:...:..:.:|.:|:.....||..|:|.|::|||||||:...::|
Human    67 DINKHGLEETAAKCKGL-GAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLF 130

  Fly   148 NPDPADVQLMINVNLTSHFWTKLVFLPKMKELRKGFIVTISSLAGVFPLPYSATYTTTKSGALAH 212
            ......::....||:.:||||...|||.|.:...|.|||::|.||...:|:...|.::|..|:..
Human   131 ATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGF 195

  Fly   213 MRTLRMELDLENQKDIHVTTVLPSFLRTNSDVTQLTHTIGFGDVYPLFTGEEVAQRIVAGMVRGE 277
            .:||..||.......:..|.:.|:|:.|.. :...:.::|     |....|||..|::.|::..:
Human   196 HKTLTDELAALQITGVKTTCLCPNFVNTGF-IKNPSTSLG-----PTLEPEEVVNRLMHGILTEQ 254

  Fly   278 AEITVPGMACLLYRVILILPADWQDRIILLFSR 310
            ..|.:|.....|..:..|||    :|.:.:..|
Human   255 KMIFIPSSIAFLTTLERILP----ERFLAVLKR 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13833	NP_651111.1	adh_short	53..241	CDD:278532	61/187 (33%)
CG13833	NP_651111.1	NADB_Rossmann	54..297	CDD:304358	72/242 (30%)
HSD17B11	NP_057329.3	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	74/249 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1201
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1373099at2759
OrthoFinder	1	1.000	-	-		FOG0000227
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24322
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920