Protein Alignment CG13833 and HSD17B3

DIOPT Version :10

• Sequence 1: NP_651111.1
• Gene: CG13833 / 42718
• FlyBaseID: FBgn0039040
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_000188.1
• Gene: HSD17B3 / 3293
• HGNCID: 5212
• Length: 310
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 86/322 - (26%)
• Similarity: 146/322 - (45%)
• Gaps: 59/322 - (18%)

  Fly    24 ITPLLILVALLGRLIA-KLC-----WCSAPKSI---AGEVAVVTGAGHGLGRAISLELAKKGCHI 79
            :|.||:.:|.|.:.:. ..|     |...|||.   .|:.||:||||.|:|:|.|.||||:|.::
Human    11 LTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNV 75

  Fly    80 AVVDINVSGAEDTVKQIQDIYKVRAKAYKANVTNYDDLVE-LNSKVVE-EMGPVTVLVNNAGVM- 141
            .::...:...|....:|:.......|..:|:.|. ||:.| :..|:.. |:|   :||||.|::
Human    76 VLISRTLEKLEAIATEIERTTGRSVKIIQADFTK-DDIYEHIKEKLAGLEIG---ILVNNVGMLP 136

  Fly   142 -MHRNMFNPDPADVQLMINVNLTSHFWTKLVFLPKMKELRKGFIVTISSLAGVFPLPYSATYTTT 205
             :..:.|...|.::|.:|:.|:||......:.|..|:..:||.|:.|||...:||.|..:.|:.:
Human   137 NLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSAS 201

  Fly   206 KSGALAHMRTLRMELDLENQKDI--------HVTTVLPSFLRTNSDVTQLTHTIGFGDVYPLFTG 262
            |:...|..:.|:.|.   ..|::        .|:|.:..:|.||    .:|.|          ..
Human   202 KAFVCAFSKALQEEY---KAKEVIIQVLTPYAVSTAMTKYLNTN----VITKT----------AD 249

  Fly   263 EEVAQRIVAGMVRGEAEITVPGMACLLYRVIL----ILPADWQDRIILLFSRNKFKKLRDEH 320
            |.|.:.:....:.||.      ..||.:.::.    ::|| |      .|....|::|...|
Human   250 EFVKESLNYVTIGGET------CGCLAHEILAGFLSLIPA-W------AFYSGAFQRLLLTH 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13833	NP_651111.1	YqjQ	49..305	CDD:440069	73/274 (27%)
HSD17B3	NP_000188.1	17beta-HSD1_like_SDR_c	48..284	CDD:187614	71/263 (27%)