Protein Alignment CG13833 and HSD11B2

DIOPT Version :10

• Sequence 1: NP_651111.1
• Gene: CG13833 / 42718
• FlyBaseID: FBgn0039040
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_000187.3
• Gene: HSD11B2 / 3291
• HGNCID: 5209
• Length: 405
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 67/275 - (24%)
• Similarity: 106/275 - (38%)
• Gaps: 60/275 - (21%)

  Fly     9 LVKLQAIIALI--GLAAITPLLILVALLGRL----------------IAKLCWCSAPK------- 48
            ||..:|::.|:  .|....|||..:|||..|                :|...|.:..:
Human    14 LVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRL 78

  Fly    49 SIAGEVAVVTGAGHGLGRAISLELAKKGCHI--AVVDINVSGAEDTVKQIQDIYKVRAKAYKANV 111
            .:|....::||...|.|:..:.:|...|..:  .|:::|..||    .:::.....|.:..:.::
Human    79 PVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGA----IELRTCCSPRLRLLQMDL 139

  Fly   112 TNYDDLVELNSKVVEEMGPVTV------LVNNAGVMMHRNMFNPDPADVQL--------MINVNL 162
            |...|:    |:|:|.....|.      ||||||       .|...||.:|        .:.||.
Human   140 TKPGDI----SRVLEFTKAHTTSTGLWGLVNNAG-------HNEVVADAELSPVATFRSCMEVNF 193

  Fly   163 TSHFWTKLVFLPKMKELRKGFIVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMELDLENQKD 227
            ..........||.::..| |.|||:.|.||..|.|....|.|:|:.....|.|...||   ....
Human   194 FGALELTKGLLPLLRSSR-GRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCEL---LPWG 254

  Fly   228 IHVTTVLPSFLRTNS 242
            :.|:.:.|...:|.|
Human   255 VKVSIIQPGCFKTES 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13833	NP_651111.1	YqjQ	49..305	CDD:440069	53/210 (25%)
HSD11B2	NP_000187.3	type2_17beta_HSD-like_SDR_c	83..363	CDD:187665	52/206 (25%)
		Essential for protein stability	335..339
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..405