DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lmd and Zxdc

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_766590.1	Gene:	Zxdc / 80292	MGIID:	1933108	Length:	858	Species:	Mus musculus

Alignment Length:	672	Identity:	142/672 - (21%)
Similarity:	233/672 - (34%)	Gaps:	219/672 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 QSPCSSP-----------HLDAWLNFNLGEISAAASSSAASPKLGNVFEEQVKEEASPAKLPSMN 267
            |.|.::|           :.|..:.|:.|..:.||:.:.|:|.|            .||..|.:.
Mouse   103 QVPAAAPGAALAGTVTIHNQDLLVRFDRGVFTLAAAPAPAAPSL------------HPATTPGLE 155

  Fly   268 -------------STFGTP--KC-IPMCASNYEDYANLYQQGSGYSTENYHNNMAQVVEKPNREH 316
                         ::.|:|  :| .|.||.:   :|..:|......|   |.::     :..|..
Mouse   156 PSSAAASRRGPVAASAGSPAYRCPEPQCALS---FAKKHQLKVHLLT---HGSL-----QGRRPF 209

  Fly   317 KAIWTIDELDELMLGEQQQFLQHHLQQQHLQEQQEQLHQPH-------GQEQQT-QNCKDDLVNY 373
            |.     .||    |....|...:..::|||...:.  :|.       |::..| .|.|..:..:
Mouse   210 KC-----PLD----GCGWAFTTSYKLKRHLQSHDKL--RPFSCPVGGCGKKFTTVYNLKAHMKGH 263

  Fly   374 LSDEFIK----AEEF---RSLDSDDDENYNEEEDDLDNDVFAPPAESDPKPDSTCCDPEAEPENE 431
            ..:...|    ||.|   ..|:|....::                               |||.
Mouse   264 EQESLFKCEVCAERFPTHAKLNSHQRSHF-------------------------------EPER- 296

  Fly   432 VIPLICRWTGCDEEFPHQQAFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVH 496
              |..|.:.||::.|....|...| .:.|  .|:.|.|||.:..|.::|   :...:|.||:|.|
Mouse   297 --PYKCDFPGCEKTFITVSALFSH-NRAH--FREQELFSCSFPGCNKQY---DKACRLKIHLRSH 353

  Fly   497 SGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRTHYDTKP 561
            :||:|..|....|...|:.:..|..|:|.|..:|.:.|..:||.|:|:.:.....|..||..|||
Mouse   354 TGERPFICDSDSCGWTFTSMSKLLRHKRKHDDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKP 418

  Fly   562 YACQLPGCTKRYTDPSSLRKHVKNHALRNANGQLRRKSAGGASVPPSGPKKAAKTRRHSESALVQ 626
            :.|.:.||..|::..|||..|.|.|        |:......:..|.|...:.. |.:||..|.|.
Mouse   419 FECPVEGCCARFSARSSLYIHSKKH--------LQDVGTPKSRCPVSSCNRLF-TSKHSMKAHVV 474

  Fly   627 RGVGAGVGVAVPSAPGDQRQHRSNSCSEALLLQQHQQQQQ--QQQQQQKQHQPENERTT------ 683
            |                                ||.::|.  .|.:......|.:|.::
Mouse   475 R--------------------------------QHSRRQDLVPQLEAPSSLTPSSELSSPGQSEL 507

  Fly   684 -----------DRSNCGTGVAANNNSMNFNELSNCIVIIE---------HNQSGGPAGPATLATA 728
                       ..:|..:..|.::.::|...|:..:..:.         :|.|.||..|..|.
Mouse   508 TNIDLAALFSDTPANSSSSTAGSDEALNSGILTIDVTSVSSSLGGNLPTNNNSLGPMDPLVLV-- 570

  Fly   729 TATTTATATYGNGNMAPAPETEVL-----SVCSGGGSSNSNSNNNRYNA----------NINQLS 778
                      .:|:|.|:.::.::     :|...|..|..:|......|          |:||.|
Mouse   571 ----------AHGDMPPSLDSPLVLGTSATVLQPGSFSADDSQAMSTGAVGCLVALPVRNLNQDS 625

  Fly   779 ELEQLLTTAK----PTGTPAAS 796
               ..||.:.    |..||.:|
Mouse   626 ---PALTPSNNLTAPGTTPTSS 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	11/25 (44%)
		C2H2 Zn finger	504..526	CDD:275368	6/21 (29%)
		C2H2 Zn finger	534..556	CDD:275368	6/21 (29%)
		C2H2 Zn finger	564..586	CDD:275368	9/21 (43%)
Zxdc	NP_766590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..108		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..175		7/44 (16%)
		C2H2 Zn finger	178..200	CDD:275368	7/27 (26%)
		zf-C2H2_aberr	209..354	CDD:293622	41/195 (21%)
		C2H2 Zn finger	211..233	CDD:275368	7/30 (23%)
		zf-H2C2_2	226..252	CDD:290200	5/27 (19%)
		C2H2 Zn finger	241..263	CDD:275368	4/21 (19%)
		C2H2 Zn finger	271..291	CDD:275368	5/19 (26%)
		C2H2 Zn finger	300..322	CDD:275368	6/22 (27%)
		C2H2 Zn finger	334..353	CDD:275368	6/21 (29%)
		C2H2 Zn finger	361..383	CDD:275368	6/21 (29%)
		zf-H2C2_2	376..402	CDD:290200	10/25 (40%)
		C2H2 Zn finger	391..413	CDD:275368	6/21 (29%)
		COG5048	392..>691	CDD:227381	63/309 (20%)
		C2H2 Zn finger	421..443	CDD:275368	9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..652		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..714
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847749
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840