Protein Alignment lmd and ZXDA

DIOPT Version :9

• Sequence 1: NP_732811.1
• Gene: lmd / 42717
• FlyBaseID: FBgn0039039
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_009087.1
• Gene: ZXDA / 7789
• HGNCID: 13198
• Length: 799
• Species: Homo sapiens
• Alignment Length: 439
• Identity: 111/439 - (25%)
• Similarity: 170/439 - (38%)
• Gaps: 100/439 - (22%)

  Fly   427 EPENEVIPLICRWTGCDEEFPHQQAFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLI 491
            |||.   |..|.::||.:.|....|...| .:.|  .|:.|.|||.:..|.::|   :...:|.|
Human   384 EPER---PYQCAFSGCKKTFITVSALFSH-NRAH--FREQELFSCSFPGCSKQY---DKACRLKI 439

  Fly   492 HMRVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRTH 556
            |:|.|:||:|..|.|.||...|:.:..|..|:|.|..:|.:.|..:||.|:|:.:.....|..||
Human   440 HLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITH 504

  Fly   557 YDTKPYACQLPGCTKRYTDPSSLRKHVKNHALRNANGQLRRKSAGGASVPPSGPKKAAKTRRHSE 621
            ..|||:.|.:.||..|::..|||..|.|.|        |:......:..|.|...|...::...:
Human   505 LGTKPFVCPVAGCCARFSARSSLYIHSKKH--------LQDVDTWKSRCPISSCNKLFTSKHSMK 561

  Fly   622 SALVQR-GVG--------AGVGVAVPSAPGDQRQHR-------------SNSCSEALL------- 657
            :.:|:| .||        |...:...|....|||:.             .:|.|.|||
Human   562 THMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLDTALVNS 626

  Fly   658 -------------LQQHQQQQQQQQQQQKQHQPENERTTD-----RSNCGTGVAA---NNNSMNF 701
                         |..|..........|....|....|:|     .::...|.||   ..:|:|.
Human   627 GILTIDVASVSSTLAGHLPANNNNSVGQAVDPPSLMATSDPPQSLDTSLFFGTAATGFQQSSLNM 691

  Fly   702 NELSNCIVIIEHNQSGGPAG-------------PATLATATATTTATATY-GNGNMAPAPETEVL 752
            :|:|:..|        ||.|             |..|..::..|..|.|. .:..:.....:|:|
Human   692 DEVSSVSV--------GPLGSLDSLAMKNSSPEPQALTPSSKLTVDTDTLTPSSTLCENSVSELL 748

  Fly   753 SVCSGGGSSNSNSN------NNRY---NANINQLSELEQLLTTAKPTGT 792
            :......|.:.||:      ..::   ||..|..|:.|:.|.|.  ||:
Human   749 TPAKAEWSVHPNSDFFGQEGETQFGFPNAAGNHGSQKERNLITV--TGS 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	13/25 (52%)
		C2H2 Zn finger	504..526	CDD:275368	8/21 (38%)
		C2H2 Zn finger	534..556	CDD:275368	6/21 (29%)
		C2H2 Zn finger	564..586	CDD:275368	9/21 (43%)
ZXDA	NP_009087.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..89
		Required for interaction with ZXDC. /evidence=ECO:0000269|PubMed:17493635	267..573		65/205 (32%)
		C2H2 Zn finger	269..291	CDD:275368
		zf-C2H2_aberr	300..445	CDD:293622	22/69 (32%)
		zf-C2H2	300..324	CDD:278523
		C2H2 Zn finger	302..324	CDD:275368
		C2H2 Zn finger	332..354	CDD:275368
		zf-H2C2_2	346..369	CDD:290200
		C2H2 Zn finger	362..382	CDD:275368
		C2H2 Zn finger	391..413	CDD:275368	6/22 (27%)
		C2H2 Zn finger	425..444	CDD:275368	6/21 (29%)
		COG5048	<437..568	CDD:227381	44/138 (32%)
		C2H2 Zn finger	452..474	CDD:275368	8/21 (38%)
		zf-H2C2_2	467..493	CDD:290200	10/25 (40%)
		C2H2 Zn finger	482..504	CDD:275368	6/21 (29%)
		C2H2 Zn finger	512..534	CDD:275370	9/21 (43%)
		Required for transcriptional activation	572..699		23/126 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157356
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840