Protein Alignment lmd and ZIC3

DIOPT Version :10

• Sequence 1: NP_732811.1
• Gene: lmd / 42717
• FlyBaseID: FBgn0039039
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_003404.1
• Gene: ZIC3 / 7547
• HGNCID: 12874
• Length: 467
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 137/456 - (30%)
• Similarity: 200/456 - (43%)
• Gaps: 118/456 - (25%)

  Fly   234 SAAASSSAASPKLGNVFEEQVKEEASPA---KLPSMNSTFGTPKCIPMCASNYEDYANLYQQGSG 295
            :|||:::||:.||            |||   .|.|..|:..||                  ||||
Human    46 AAAAAAAAAAFKL------------SPAAAHDLSSGQSSAFTP------------------QGSG 80

  Fly   296 YST--------ENYHNNMAQVVEKPNREHKAIWTIDELDELMLGEQQQFL--------QHHLQQQ 344
            |:.        .::|::.:||   |:....|....:...|.:..::...|        ||.|
Human    81 YANALGHHHHHHHHHHHTSQV---PSYGGAASAAFNSTREFLFRQRSSGLSEAASGGGQHGL--- 139

  Fly   345 HLQEQQEQLHQPHG-------------QEQ------QTQNCKDDLVNY-LSDE-FIKAEEFRSLD 388
             .......||.|.|             .||      .|.:..::.|:. |..| |.:|:.:|.:.
Human   140 -FAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRPVA 203

  Fly   389 SDDDE---------NYNEEEDDLDNDVFAPPAESDPKPDSTCCDPEA------EPENEVIPLICR 438
            |...:         ||:....::..:|.|...            |.|      :|..:  .|.|:
Human   204 SPRTDPYAAGAQFPNYSPMNMNMGVNVAAHHG------------PGAFFRYMRQPIKQ--ELSCK 254

  Fly   439 W----------TGCDEEFPHQQAFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHM 493
            |          ..||..|......|.|:...||...:..:..|:|.:|||..|.|.|:|||:.|:
Human   255 WIDEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHI 319

  Fly   494 RVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRTHYD 558
            |||:||||..||||||.|.|:|.||||||:|:||||:|:.|:::||.:.|:|||||.||...|..
Human   320 RVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTS 384

  Fly   559 TKPYACQLPGCTKRYTDPSSLRKHVKNHALRNANGQLRRKSAGGASVPPSGPKKAAKTRRHSESA 623
            .|||.|::  |.|.||.|||||||:|.|..:.::......|...:|.||:.....:|....:.||
Human   385 DKPYICKV--CDKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESSTPPAIASANSKDTTKTPSA 447

  Fly   624 L 624
            :
Human   448 V 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	SFP1	<493..585	CDD:227516	55/91 (60%)
		C2H2 Zn finger	504..526	CDD:275368	16/21 (76%)
		C2H2 Zn finger	534..556	CDD:275368	11/21 (52%)
		C2H2 Zn finger	564..586	CDD:275368	13/21 (62%)
ZIC3	NP_003404.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..107		14/61 (23%)
		zf_ZIC	245..290	CDD:436441	11/46 (24%)
		Nuclear localization signal	297..322		13/24 (54%)
		C2H2 Zn finger	302..322	CDD:275368	11/19 (58%)
		SFP1	<324..408	CDD:227516	52/85 (61%)
		C2H2 Zn finger	330..352	CDD:275368	16/21 (76%)
		Nuclear localization signal	330..352		16/21 (76%)
		C2H2 Zn finger	360..382	CDD:275368	11/21 (52%)
		C2H2 Zn finger	390..410	CDD:275368	13/21 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..467		12/45 (27%)