Protein Alignment lmd and SP4

DIOPT Version :10

• Sequence 1: NP_732811.1
• Gene: lmd / 42717
• FlyBaseID: FBgn0039039
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_003103.2
• Gene: SP4 / 6671
• HGNCID: 11209
• Length: 784
• Species: Homo sapiens
• Alignment Length: 737
• Identity: 145/737 - (19%)
• Similarity: 241/737 - (32%)
• Gaps: 225/737 - (30%)

  Fly     5 LKTSQSGG----MYVKTSSISGISSISGKEAASCYGGFMSPPLSANITANNGEREMFRVPGAKVE 65
            |.|:|..|    :...|...|..:::|...::|          |::.::|||.....:.......
Human    92 LVTTQLAGNAWQLVASTPPASKENNVSQPASSS----------SSSSSSNNGSASPTKTKSGNSS 146

  Fly    66 TNESYACGELQFPDFSHLCFAAETPNSVFSDCHNYAGQDQQ---------QDSDQDDIVCAAAEN 121
            |...:...::|.|       :......|........||..|         ||. |..|...:|.|
Human   147 TPGQFQVIQVQNP-------SGSVQYQVIPQLQTVEGQQIQINPTSSSSLQDL-QGQIQLISAGN 203

  Fly   122 TGMPYQQGQYTQLNREDIFRFEPEDIARLTGESEL-PGM---LQHPQTPYTPYTPYTPYTPCSAQ 182
                 .|...|..||........:::|..|...:: ||:   ||....|.|.....|. .|.:..
Human   204 -----NQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTT-LPINIG 262

  Fly   183 NSQYAVQPAND-------------SINLDIDYFNYDEI---------NCQSKNQSPCSSPHLDAW 225
            ....|:...|:             :...|....|.:::         :..:..:||.||......
Human   263 GVTLALPVINNVAAGGGTGQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTT 327

  Fly   226 LNFNLGE----ISAA-----ASSSAASPKLGNVFEEQVKEEASPAKLPSMNSTFGTPKCIPMCAS 281
            .:.:|..    :|:|     ||:||:|.      |..::|..:||...|  ....:.:..|....
Human   328 ASTSLTSSDTLVSSADTGQYASTSASSS------ERTIEESQTPAATES--EAQSSSQLQPNGMQ 384

  Fly   282 NYEDYANLYQQGSGYSTENYHNNMAQVVEKPNREHKAIWTIDELDELMLGEQQQFLQHHLQQQHL 346
            |.:|.:|..||             .|:|.:|           .|.::.:.:.||.:...:..|..
Human   385 NAQDQSNSLQQ-------------VQIVGQP-----------ILQQIQIQQPQQQIIQAIPPQSF 425

  Fly   347 QEQQEQLHQPHGQEQQTQNCKDDLVN---------------YLSDEFIKAEEFRSLDSDDDENYN 396
            |.|..|..|.. |:|..||.:...||               .:|.:.::.:..:||     .|..
Human   426 QLQSGQTIQTI-QQQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSL-----SNLQ 484

  Fly   397 EEEDDLDNDVFAPPAESDP-------KPDSTCCDP-----------------------EAEPENE 431
            .:...|...:...|..|..       .|.:....|                       .|..:.:
Human   485 VQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQ 549

  Fly   432 VIPLICRWTGCDEE----FPHQQAFV--------------------EHIEKCHV---------DV 463
            .:|:........::    ...|||.:                    :.:.:.|:         :|
Human   550 GVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDQEV 614

  Fly   464 RKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGE-----KPNK-----CPFPGCNKAFSRLEN 518
            :.|:........||      |.|          .||     :|.|     |...||.|.:.:..:
Human   615 QPGKRLRRVACSCP------NCR----------EGEGRGSNEPGKKKQHICHIEGCGKVYGKTSH 663

  Fly   519 LKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRTHYDTKPYACQLPGCTKRYTDPSSLRKHV 583
            |:.|.|.||||||:.|.:..|.|.|:.|.:..:|:|||...|.:.|  |.|:||:.....|.|||
Human   664 LRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFEC--PECSKRFMRSDHLSKHV 726

  Fly   584 KNHALRNANGQLRRKSAGGASV 605
            |.|         :.|..||.::
Human   727 KTH---------QNKKGGGTAL 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	SFP1	<493..585	CDD:227516	36/101 (36%)
		C2H2 Zn finger	504..526	CDD:275368	7/21 (33%)
		C2H2 Zn finger	534..556	CDD:275368	7/21 (33%)
		C2H2 Zn finger	564..586	CDD:275368	10/21 (48%)
SP4	NP_003103.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68
		SP4_N	32..648	CDD:411773	108/633 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..150		8/50 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..390		22/116 (19%)
		9aaTAD, inactive. /evidence=ECO:0000269|PubMed:31375868	467..475		1/7 (14%)
		zf-C2H2	647..671	CDD:395048	7/23 (30%)
		C2H2 Zn finger	649..671	CDD:275368	7/21 (33%)
		zf-C2H2	677..701	CDD:395048	7/23 (30%)
		C2H2 Zn finger	679..701	CDD:275368	7/21 (33%)
		zf-H2C2_2	693..716	CDD:463886	9/24 (38%)
		zf-C2H2	707..729	CDD:395048	10/23 (43%)
		C2H2 Zn finger	709..729	CDD:275368	10/21 (48%)