DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lmd and Zic5

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_075363.1	Gene:	Zic5 / 65100	MGIID:	1929518	Length:	622	Species:	Mus musculus

Alignment Length:	314	Identity:	113/314 - (35%)
Similarity:	141/314 - (44%)	Gaps:	71/314 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 APPAESDPKPDSTCCDPEAEPENEVIP-----------------LICRWTG-------------- 441
            |||....|.       |...|.:..:|                 |||:|..
Mouse   329 APPPAPPPA-------PAPHPHHPHLPGAAGAFLRYMRQPIKRELICKWLDPEELAGPPASADSG 386

  Fly   442 ---CDEEFPHQQAFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNK 503
               |.:.|......|.|:...||...:.....|||.||||..|||.|:|||:.|:|||:||||..
Mouse   387 VKPCSKTFGTMHELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKPFP 451

  Fly   504 CPFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRTHYDTKPYACQLPG 568
            ||||||.|.|:|.||||||:|:||||:|:.|::.||.:.|:|||||.||...|...|||.|::.|
Mouse   452 CPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYYCKIRG 516

  Fly   569 CTKRYTDPSSLRKHVKNHALRNANGQLRRKSAGGASVPPSGPKKAAKTRRHSESALVQRGVGAGV 633
            |.|.||.|||||||:|.|.          ||      ||..|           .||....||..|
Mouse   517 CDKSYTHPSSLRKHMKIHC----------KS------PPPSP-----------GALGYSSVGTPV 554

  Fly   634 GVAVPSAPG-DQRQHRSNSCSEALLLQQHQQQQQQQQQQQKQHQPENERTTDRS 686
            |  .|.:|. |..:.||::.|..:.........|........|.|.:..||..|
Mouse   555 G--DPLSPVLDPTRSRSSTLSPQVTNLNEWYVCQASGAPSHLHTPSSNGTTSES 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	17/25 (68%)
		C2H2 Zn finger	504..526	CDD:275368	16/21 (76%)
		C2H2 Zn finger	534..556	CDD:275368	11/21 (52%)
		C2H2 Zn finger	564..586	CDD:275368	14/21 (67%)
Zic5	NP_075363.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..171
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..223
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..251
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..349		6/26 (23%)
		COG5048	<388..550	CDD:227381	86/188 (46%)
		C2H2 Zn finger	424..444	CDD:275368	12/19 (63%)
		zf-H2C2_2	437..463	CDD:290200	17/25 (68%)
		C2H2 Zn finger	452..474	CDD:275368	16/21 (76%)
		zf-H2C2_2	466..493	CDD:290200	15/26 (58%)
		C2H2 Zn finger	482..504	CDD:275368	11/21 (52%)
		zf-C2H2	510..534	CDD:278523	15/23 (65%)
		C2H2 Zn finger	512..534	CDD:275368	14/21 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..573		18/70 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..622		5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268347at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19818
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020