Protein Alignment lmd and gli2b

DIOPT Version :10

• Sequence 1: NP_732811.1
• Gene: lmd / 42717
• FlyBaseID: FBgn0039039
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_001015069.1
• Gene: gli2b / 548610
• ZFINID: ZDB-GENE-050523-1
• Length: 1363
• Species: Danio rerio
• Alignment Length: 746
• Identity: 201/746 - (26%)
• Similarity: 289/746 - (38%)
• Gaps: 219/746 - (29%)

  Fly   219 SPHLDAWLNF-----NLGEISAAASSSAASPKLGNVFEEQVKEE----------ASPAKLPSMNS 268
            |||::.:|..     .|..||||...|.|     .|..|.:||.          ||||..
Zfish   109 SPHVEHYLRSAHSSPTLSMISAARGLSPA-----EVAHEHLKERGLFGLPPPPGASPADY----- 163

  Fly   269 TFGTPKCIPMCASNYEDYANLYQQGSGYSTENYH----------NNMAQVVEKPNREHKAIWTID 323
                   ..:.|.:...|..|..||:|.:....|          :........|....|...:|.
Zfish   164 -------YHLMAGHRNPYGELLMQGAGAAAAAAHLPEYFTSVDVSRFPSPRMTPRLSRKRALSIS 221

  Fly   324 ELDELMLGEQQQ----------FLQH------------HLQ-------------------QQHLQ 347
            .|.:..:..|..          ::.:            ||.                   ||.|.
Zfish   222 PLSDASIDLQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVGGISPSFPFPHSINPVAYQQLLT 286

  Fly   348 EQQ--------------------------EQLHQPHGQEQQTQNCKDD-----LVNYLSDEFIKA 381
            :|:                          ..|..|...:.:|:|...:     .||.|.::..|.
Zfish   287 QQRGLSAFGHTPPLIQPSPTFSSRHPLSLSTLPTPTTNDTETKNSNGESAVSSTVNPLGNKRSKV 351

  Fly   382 EEF----RSLDSDDDENYNEEED---DLDNDVFAPPAESDPKPDSTCCDPEAEPENEVIPLICRW 439
            :..    |.:.....|:.:..:|   |:|:                 |..|||   .|....|.|
Zfish   352 KTELGGPRPVSPYSPEHLSSAQDLKEDMDD-----------------CKQEAE---LVYETNCHW 396

  Fly   440 TGCDEEFPHQQAFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKC 504
            .||.:|:..|:..|.||...|:...| ::|.|.|.:|.|..|||.|:|.|::|||.|:||||:||
Zfish   397 EGCSKEYDTQEQLVHHINNEHIHGEK-KEFVCRWDECSREQKPFKAQYMLVVHMRRHTGEKPHKC 460

  Fly   505 PFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKPYACQLPG 568
            .|.||:||:|||||||.|.||||||:||.|:::||.|||||:||||||| |||.:.|||.|::||
Zfish   461 TFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPG 525

  Fly   569 CTKRYTDPSSLRKHVKNHALRNANGQLRRKSAGGASVPPSGPK----------------KAAKTR 617
            ||||||||||||||||  .:......:.:|..|.....|..||                :|..|.
Zfish   526 CTKRYTDPSSLRKHVK--TVHGPEAHVTKKQRGDLPSRPHPPKENGENEAGAKMAEEKIEANSTT 588

  Fly   618 RHSESALVQRGVGAGVGVAVPSAPGDQRQHRSNSCSEALLLQQHQQQQQQQQQQQKQHQPENERT 682
            |..|..|..:.:.....:...|:||.|     :|||.                       |....
Zfish   589 RGVEDYLQVKSIKTENSMMYQSSPGGQ-----SSCSS-----------------------EPSPL 625

  Fly   683 TDRSNCGTGV-AANNNSMNFNELS--NCIVIIEHNQSGG--------PAGPATLAT-----ATAT 731
            ...|..|.|| .|..:..:..:||  :.:.|::...|.|        .||||...|     ...:
Zfish   626 GSASLHGGGVEPAGLSGGSVGDLSALDDVPIVDSTVSTGILGLHLRKNAGPAHRLTHLKQEKLKS 690

  Fly   732 TTATATYGNGNMAPAPETEVLSV---------CSGGGSSNSNSNNNRYNANINQLSEL----EQL 783
            ...:.::.| ...|||.|::..:         |..|.|.:|....:........||:|    :.|
Zfish   691 VRDSCSWAN-TAPPAPCTKLPPINTGSLLDGLCDPGLSISSPRLGDLCPGETTVLSQLVERRDSL 754

  Fly   784 LTTAKPTGTPAASANGISLANNNGRANGDSK 814
            .:|.....|.:..::|||...::.|::..|:
Zfish   755 ASTVSSAYTFSRRSSGISPCYSSRRSSQTSQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	SFP1	<493..585	CDD:227516	69/92 (75%)
		C2H2 Zn finger	504..526	CDD:275368	15/21 (71%)
		C2H2 Zn finger	534..556	CDD:275368	16/22 (73%)
		C2H2 Zn finger	564..586	CDD:275368	19/21 (90%)
gli2b	NP_001015069.1	C2H2 Zn finger	430..452	CDD:275368	11/21 (52%)
		SFP1	<454..544	CDD:227516	67/91 (74%)
		C2H2 Zn finger	460..482	CDD:275368	15/21 (71%)
		C2H2 Zn finger	490..513	CDD:275368	16/22 (73%)
		C2H2 Zn finger	521..542	CDD:275368	19/22 (86%)