DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lmd and MTF1

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_005946.2	Gene:	MTF1 / 4520	HGNCID:	7428	Length:	753	Species:	Homo sapiens

Alignment Length:	688	Identity:	151/688 - (21%)
Similarity:	219/688 - (31%)	Gaps:	270/688 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 DEN---YNEEEDDL----------DNDVFAPPA------------ESDPKPDSTCCDPEAEPE-N 430
            |.|   :..|||:|          |.:...|.:            |.||   .|..|.:.:.: .
Human     7 DNNIIYFEAEEDELTPDDKMLRFVDKNGLVPSSSGTVYDRTTVLIEQDP---GTLEDEDDDGQCG 68

  Fly   431 EVIPLICRWTGCDEEF---PHQ---QAFVEHI---EKCHVDVRKG-------------------- 466
            |.:|.:   .|.:|.|   .|:   |.:|:||   ::.|:.:..|
Human    69 EHLPFL---VGGEEGFHLIDHEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECP 130

  Fly   467 -------EDFSCFWLDCPRRY---------------------------KPFNARYKLLIHMRVHS 497
                   :.:.|.:..|||.|                           |.|...|.|.||:|||:
Human   131 ETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHT 195

  Fly   498 GEKPNKCPFPGCNKAFSRLENLKIHQ-----------------------------RSHTGERPYG 533
            .|||.:|...||.|||:.|..||.||                             |:||||:|:.
Human   196 KEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFR 260

  Fly   534 CQYKGCLKAFSNSSDRAKHQRTHYDTKPYACQLPGCTKRYTDPSSLRKHVKNH--------ALRN 590
            |.:.||.|||:.|.....|.|||...:|:.|...||.|.::...||:.|:|.|        ||..
Human   261 CDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGHSYNALPQ 325

  Fly   591 ANG--------------------QLRRKSA----------------------------------- 600
            .||                    :||..|:
Human   326 HNGSEDTNHSLCLSDLSLLSTDSELRENSSTTQGQDLSTISPAIIFESMFQNSDDTAIQEDPQQT 390

  Fly   601 --------GGA----SVPPSGPKKAAKTRRHSESALVQRGVG--------AGVGVAVPSA----P 641
                    |.|    .||||....|:.    |...::|.|:.        |....|.|.|    |
Human   391 ASLTESFNGDAESVSDVPPSTGNSASL----SLPLVLQPGLSEPPQPLLPASAPSAPPPAPSLGP 451

  Fly   642 GDQRQHRSNSCSEALLLQ------QHQQQQQQQQQQQKQHQPENERTTDRSNCGTGVAANNNSMN 700
            |.|:....|   ...|||      .|..|.....|:...|....:......:...|.:|:..:
Human   452 GSQQAAFGN---PPALLQPPEVPVPHSTQFAANHQEFLPHPQAPQPIVPGLSVVAGASASAAA-- 511

  Fly   701 FNELSNCIVIIEHNQSGGPAGPATL------ATATATTTATATYGNGNMAPAPETEVL--SVCSG 757
               :::.:......||.....||.:      |.:..|...|.|     :.|.|.|.:|  |:..|
Human   512 ---VASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTNNPTIT-----ITPTPNTAILQSSLVMG 568

  Fly   758 --------GGSSNSNSNNNRYNANINQLSELEQL-LTTAKP-TGTPAASANGISLA------NNN 806
                    .|:::|..|..:    |.|.|::|:: .|||.| ..:|.:|...|.|:      ...
Human   569 EQNLQWILNGATSSPQNQEQ----IQQASKVEKVFFTTAVPVASSPGSSVQQIGLSVPVIIIKQE 629

  Fly   807 GRANGDSKCHLSEFVSFEYVTKYLTDVYEPQCKSPQPP 844
            ........|..|        .|.........|.||.||
Human   630 EACQCQCACRDS--------AKERASSRRKGCSSPPPP 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	15/25 (60%)
		C2H2 Zn finger	504..526	CDD:275368	12/50 (24%)
		C2H2 Zn finger	534..556	CDD:275368	9/21 (43%)
		C2H2 Zn finger	564..586	CDD:275368	8/21 (38%)
MTF1	NP_005946.2	COG5048	<93..291	CDD:227381	51/197 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	133..138		0/4 (0%)
		C2H2 Zn finger	145..164	CDD:275368	4/18 (22%)
		zf-H2C2_2	156..183	CDD:290200	2/26 (8%)
		C2H2 Zn finger	172..194	CDD:275368	7/21 (33%)
		zf-H2C2_2	186..213	CDD:290200	15/26 (58%)
		C2H2 Zn finger	202..224	CDD:275368	11/21 (52%)
		zf-C2H2_8	231..319	CDD:292531	27/87 (31%)
		C2H2 Zn finger	234..253	CDD:275368	1/18 (6%)
		zf-H2C2_2	245..271	CDD:290200	11/25 (44%)
		C2H2 Zn finger	261..283	CDD:275368	9/21 (43%)
		zf-H2C2_2	275..302	CDD:290200	9/26 (35%)
		C2H2 Zn finger	291..313	CDD:275368	8/21 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..328		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..466		19/77 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	648..715		5/12 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19818
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010