DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lmd and zic3

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001001950.1	Gene:	zic3 / 368263	ZFINID:	ZDB-GENE-030708-2	Length:	448	Species:	Danio rerio

Alignment Length:	445	Identity:	133/445 - (29%)
Similarity:	185/445 - (41%)	Gaps:	95/445 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 LGEISAAASSSAASPKLGNVFEEQVKEEASPAKLPSMNSTFGTPKCIPMCAS---NYEDYANLYQ 291
            ||....|.||.:|:.|:..|..:...         |..|.| ||:.....|:   ::......|.
Zfish    34 LGLSPFADSSHSAAFKISPVTHDIAS---------SQTSAF-TPQATGYAAALGHHHGGQVGSYA 88

  Fly   292 QGSGYSTEN--YHNNMAQVVE--KPNREHKAIWTI------------DELDELML-GEQQQFLQH 339
            .|:..||.:  :.|..|.:.|  .|:.:| .|:..            |....|:. |...|.:.|
Zfish    89 GGAFNSTRDFLFRNRGAGIGETAPPSAQH-GIFAASAGSLHGPPGISDNPGHLLFPGLHDQSVSH 152

  Fly   340 HLQQQHLQEQQEQLHQPHGQEQQTQNCKDDLVNYLSDEFIKAEEFRSLDSDDDENYNEEEDDLDN 404
            .....|:...|..|                  ....|.|.:.:.:|.:.|...|.|.
Zfish   153 TSPGGHVVNSQMHL------------------GLRGDIFGRPDPYRPVASPRTEPYG-------- 191

  Fly   405 DVFAPPAESDPKPDS--------TCCDPEA------EPENEVIPLICRWTG----------CDEE 445
               |.|..:...|.:        |...|.|      :|..:  .|.|:|..          ||..
Zfish   192 ---AAPLHNYNHPINMNMGMNVPTHHGPGAFFRYMRQPIKQ--ELSCKWIDENQMNRPKKTCDRT 251

  Fly   446 FPHQQAFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCN 510
            |......|.|:...||...:..:..|:|.||||..|.|.|:|||:.|:|||:||||..||||||.
Zfish   252 FSTMHEMVTHVSMEHVGGPEQSNHVCYWEDCPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCG 316

  Fly   511 KAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRTHYDTKPYACQLPGCTKRYTD 575
            |.|:|.||||||:|:||||:|:.|::.||.:.|:|||||.||...|...|||.|::  |.|.||.
Zfish   317 KIFARSENLKIHKRTHTGEKPFKCEFDGCDRRFANSSDRKKHMHVHTSDKPYICKV--CDKSYTH 379

  Fly   576 PSSLRKHVKNHALRNANGQLRRKSAGGASVPP-------SGPKKAAKTRRHSESA 623
            |||||||:|.|..:.:.......|...:|.||       ..|.|...:...:.||
Zfish   380 PSSLRKHMKVHESQGSESSPAASSGYESSTPPVLVSANTEDPTKTPTSAVQNSSA 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	17/25 (68%)
		C2H2 Zn finger	504..526	CDD:275368	16/21 (76%)
		C2H2 Zn finger	534..556	CDD:275368	11/21 (52%)
		C2H2 Zn finger	564..586	CDD:275368	13/21 (62%)
zic3	NP_001001950.1	C2H2 Zn finger	282..302	CDD:275368	11/19 (58%)
		zf-H2C2_2	295..321	CDD:290200	17/25 (68%)
		C2H2 Zn finger	310..332	CDD:275368	16/21 (76%)
		zf-H2C2_2	324..351	CDD:290200	15/26 (58%)
		C2H2 Zn finger	340..362	CDD:275368	11/21 (52%)
		zf-H2C2_2	354..379	CDD:290200	12/26 (46%)
		zf-C2H2	368..390	CDD:278523	14/23 (61%)
		C2H2 Zn finger	370..390	CDD:275368	13/21 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19818
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010