DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lmd and Zxdc

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_002729441.4	Gene:	Zxdc / 362399	RGDID:	1561296	Length:	878	Species:	Rattus norvegicus

Alignment Length:	648	Identity:	137/648 - (21%)
Similarity:	223/648 - (34%)	Gaps:	198/648 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 QSPCSSP-----------HLDAWLNFNLGEISAAAS------------------SSAASPKLGNV 249
            |.|.::|           :.|..:.|:.|..:.||:                  ||||:.:.|.|
  Rat   125 QVPAAAPGAALAGTVTIHNQDLLVRFDRGVFTLAAAPAPATQGLHPATTPGLEPSSAAASRRGPV 189

  Fly   250 FEEQVKEEASPA-KLPSMNSTFGTPKCIPMCASNYEDYANLYQQGSGYSTENYHNNMAQVVEKPN 313
                .....||| :.|.       |:|....|..::...:|...||               .:..
  Rat   190 ----AASAGSPAYRCPE-------PQCALSFAKKHQLKVHLLTHGS---------------LQGR 228

  Fly   314 REHKAIWTIDELDELMLGEQQQFLQHHLQQQHLQEQQEQLHQPH-------GQEQQT-QNCKDDL 370
            |..|.     .||    |....|...:..::|||...:.  :|.       |::..| .|.|..:
  Rat   229 RPFKC-----PLD----GCGWAFTTSYKLKRHLQSHDKL--RPFSCPVGGCGKKFTTVYNLKAHM 282

  Fly   371 VNYLSDEFIK----AEEF---RSLDSDDDENYNEEEDDLDNDVFAPPAESDPKPDSTCCDPEAEP 428
            ..:..:...|    ||.|   ..|:|....::                               ||
  Rat   283 KGHEQESLFKCEVCAERFPTHAKLNSHQRSHF-------------------------------EP 316

  Fly   429 ENEVIPLICRWTGCDEEFPHQQAFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHM 493
            |.   |..|.:.||::.|....|...| .:.|  .|:.|.|||.:..|.::|   :...:|.||:
  Rat   317 ER---PYKCDFPGCEKTFITVSALFSH-NRAH--FREQELFSCSFPGCNKQY---DKACRLKIHL 372

  Fly   494 RVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRTHYD 558
            |.|:||:|..|....|...|:.:..|..|:|.|..:|.:.|..:||.|:|:.:.....|..||..
  Rat   373 RSHTGERPFICDSDSCGWTFTSMSKLLRHKRKHDDDRRFTCPVEGCGKSFTRAEHLKGHSITHLG 437

  Fly   559 TKPYACQLPGCTKRYTDPSSLRKHVKNHALRNANGQLRRKSAGGASVPPSGPKKAAKTRRHSESA 623
            |||:.|.:.||..|::..|||..|.|.|        |:......:..|.|...:.. |.:||
  Rat   438 TKPFECPVEGCCARFSARSSLYIHSKKH--------LQDVGTPKSRCPVSSCNRLF-TSKHS--- 490

  Fly   624 LVQRGVGAGVGVAVPSAPGDQRQHRSNSCSEALLLQQHQQQQQ--QQQQQQKQHQPENERTTDRS 686
                                         .:|.:::||.::|.  .|.:......|.:|.
  Rat   491 -----------------------------MKAHMVRQHSRRQDLVPQLEAPSSLTPSSEL----- 521

  Fly   687 NCGTGVAANNNSMNFNELSNCIVIIEHNQSGGPAGPATLATATATTTATATYG-----NGNMAPA 746
                      :|...:||:|..:             |.|.:.|...::::|.|     |..:...
  Rat   522 ----------SSPGQSELTNIDL-------------AALFSDTPANSSSSTAGSDEALNSGILTI 563

  Fly   747 PETEVLSVCSGGGSSNSNSNNNRYNANINQLSELEQLLTTAKPTGTPAASANGISLANNNGRA 809
            ..|.|.|...|...:|:||........:...|::...|.:....||||......|.:.::.:|
  Rat   564 DVTSVSSSLGGNLPTNNNSLGPMDPLVLVAHSDMPPSLDSPLVLGTPATVLQPGSFSADDSQA 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	11/25 (44%)
		C2H2 Zn finger	504..526	CDD:275368	6/21 (29%)
		C2H2 Zn finger	534..556	CDD:275368	6/21 (29%)
		C2H2 Zn finger	564..586	CDD:275368	9/21 (43%)
Zxdc	XP_002729441.4	COG5048	<198..385	CDD:227381	54/259 (21%)
		C2H2 Zn finger	200..222	CDD:275368	5/28 (18%)
		C2H2 Zn finger	233..255	CDD:275368	7/30 (23%)
		zf-C2H2_8	263..340	CDD:406359	19/110 (17%)
		C2H2 Zn finger	263..285	CDD:275368	4/21 (19%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		C2H2 Zn finger	322..344	CDD:275368	6/22 (27%)
		C2H2 Zn finger	356..375	CDD:275368	6/21 (29%)
		C2H2 Zn finger	383..405	CDD:275368	6/21 (29%)
		zf-H2C2_2	398..424	CDD:404364	10/25 (40%)
		C2H2 Zn finger	413..435	CDD:275368	6/21 (29%)
		COG5048	414..>692	CDD:227381	58/282 (21%)
		C2H2 Zn finger	443..465	CDD:275368	9/21 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840