DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment lmd and Glis2

DIOPT Version :9

Sequence 1:NP_732811.1 Gene:lmd / 42717 FlyBaseID:FBgn0039039 Length:866 Species:Drosophila melanogaster
Sequence 2:XP_038941774.1 Gene:Glis2 / 302946 RGDID:1309177 Length:522 Species:Rattus norvegicus


Alignment Length:477 Identity:146/477 - (30%)
Similarity:194/477 - (40%) Gaps:130/477 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   410 PAES--DPKPDSTCCDPEAEPENEVIPLICRWTGCDEEFPHQQAFVEHIEKCHVDVRKGEDFSCF 472
            ||.|  .| |...|..||.....:   |:|||..|::.|...|..|:|:...||...:...:.|.
  Rat   145 PASSFLTP-PKDKCLSPELPLAKQ---LVCRWAKCNQLFELLQDLVDHVNDHHVKPEQDARYCCH 205

  Fly   473 WLDCPRRYKPFNA-RYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYGCQY 536
            |..|.|..:.||| |||:|||:|.|:.|||::|  |.|||:||||||||||.||||||:||.|.|
  Rat   206 WEGCARHGRGFNASRYKMLIHIRTHTNEKPHRC--PTCNKSFSRLENLKIHNRSHTGEKPYVCPY 268

  Fly   537 KGCLKAFSNSSDRAKHQRTHYDTKPYACQLPGCTKRYTDPSSLRKHVKNHALRNANG-----QLR 596
            :||.|.:||||||.||.||||..|||.|::|||.||||||||||||:|.|....::.     |||
  Rat   269 EGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSLRKHIKAHGHFVSHEQQELLQLR 333

  Fly   597 RKSAGGASVPPSGP-KKAAKTRRHSESALVQRGVGAGVGVAVPSAPGDQRQHRSNSCSEALLLQQ 660
            .........|.||. ...|:....:.:||.  |..:..|:.:|.|||                  
  Rat   334 PPPKPPLPTPDSGSYVSGAQIIIPNPAALF--GGPSLPGLPLPLAPG------------------ 378

  Fly   661 HQQQQQQQQQQQKQHQPENERTTDRS--NCGTGVAANNNSMNFNELSNCIVIIEHNQSGGPAGPA 723
                                 ..|.|  .||.|                      ...||..||.
  Rat   379 ---------------------PLDLSALACGNG----------------------GGGGGGMGPG 400

  Fly   724 TLATATATTTA-----TATYGNGNMAPAPETEVLSVCSGGGSSNSNSNNNRYNANI--------- 774
            ...:......|     .:.:|.|.:. .|...:|     |||:.|.:...:...::         
  Rat   401 LPGSVLPLNLAKNPLLPSPFGAGGLG-LPVVSLL-----GGSAGSKAEGEKGRGSVPARVLGLED 459

  Fly   775 --NQLSELEQLLTTAKPTGTPAASANGISLANNNGRANGDSKCHLSEFVSFEYVTKYLTDVYEPQ 837
              ..|...|:..:...|.|.|......:.|:..|..|:                        .|:
  Rat   460 HKTSLERTERSRSRPSPDGLPLLPGTVLDLSTGNSAAS------------------------SPE 500

  Fly   838 CKSPQ----PPANFHLQPEFDN 855
            ..:|.    ||.:..|:|...|
  Rat   501 ALTPGWVVIPPGSVLLKPAVVN 522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lmdNP_732811.1 zf-H2C2_2 489..515 CDD:290200 14/25 (56%)
C2H2 Zn finger 504..526 CDD:275368 16/21 (76%)
C2H2 Zn finger 534..556 CDD:275368 14/21 (67%)
C2H2 Zn finger 564..586 CDD:275368 17/21 (81%)
Glis2XP_038941774.1 C2H2 Zn finger 213..230 CDD:275368 10/16 (63%)
COG5048 234..>328 CDD:227381 63/95 (66%)
C2H2 Zn finger 238..258 CDD:275368 16/21 (76%)
C2H2 Zn finger 266..288 CDD:275368 14/21 (67%)
C2H2 Zn finger 296..318 CDD:275368 17/21 (81%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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