Protein Alignment lmd and gli2a

DIOPT Version :10

• Sequence 1: NP_732811.1
• Gene: lmd / 42717
• FlyBaseID: FBgn0039039
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_571042.1
• Gene: gli2a / 30154
• ZFINID: ZDB-GENE-990706-8
• Length: 1439
• Species: Danio rerio
• Alignment Length: 836
• Identity: 215/836 - (25%)
• Similarity: 315/836 - (37%)
• Gaps: 234/836 - (27%)

  Fly   124 MPYQQGQYTQLNREDIFRFEPEDIARLTGESELPGMLQHPQTPYTPYTPYTPYTPCSAQNSQYAV 188
            |.:.:|:|         .:||..:..:.|...|.|      :|..........:|.:|...:...
Zfish    54 MRHHEGRY---------HYEPHPLHPMHGPHGLAG------SPVISDISLIRLSPHAAATGESPF 103

  Fly   189 QPANDSINLDIDYFNYDEINCQSKNQSPCSSPHLDAWLNFNLGEISAAASSSAASPKLGNVFEEQ 253
            .|.:..:|..::::      .:|.:.||            .|..||||...|.|     .:..|.
Zfish   104 NPPHPYVNPHMEHY------LRSVHSSP------------TLSMISAARGLSPA-----ELTHEH 145

  Fly   254 VKEEASPAKLPSMNSTFGTPKCIP---------MCASNYEDYANLYQQGSGYSTENYHNNMAQVV 309
            :||          .|.||.|...|         :.||:...|.:|..| :|.:..:..:.|:.|.
Zfish   146 LKE----------RSLFGLPPPPPGANPSEYYHLIASHRSPYGDLLMQ-TGAAAAHLPDYMSPVD 199

  Fly   310 EK--------PNREHKAIWTIDELDELMLGEQQQ----------FLQH------------HLQ-- 342
            ..        |....|...:|..:.:..:..|..          ::.:            ||.
Zfish   200 MSRFPSPRLTPRVSRKRALSISPVSDASIDLQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVG 264

  Fly   343 ----------------QQHLQEQQEQLH---------QPH---GQEQQTQNCKDDLVNYLSDEFI 379
                            ...|..||..|:         ||.   ...|||......|.|..|
Zfish   265 AISPSFTFPHPITPVAYHQLLSQQRGLNAFGHTPPLLQPSPALSSRQQTLVAAAALNNTTS---- 325

  Fly   380 KAEEFRSLDSDDDENYNEEEDDLDNDVFAP--------PAESD-PKP---------------DST 420
            .:....:.|:..:.:.|...|...:....|        ..|:: |.|               |..
Zfish   326 SSTSSSTADTSTESSQNAGGDPAVSSTVNPMIFKRSKVKTEAEGPHPISPGSQDHLELREELDKD 390

  Fly   421 CC--DPEAEPENEVIPLICRWTGCDEEFPHQQAFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPF 483
            .|  :|||..|..     |.|.||.:|:..|...|.||...|:...| ::|.|.|::|.|..|||
Zfish   391 ECKQEPEAVYETN-----CHWEGCAKEYDTQDQLVHHISNDHIHGEK-KEFVCRWVECSREQKPF 449

  Fly   484 NARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSD 548
            .|:|.|::|||.|:||||:||.|.||:||:|||||||.|.||||||:||.|:::||.|||||:||
Zfish   450 KAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASD 514

  Fly   549 RAKHQ-RTHYDTKPYACQLPGCTKRYTDPSSLRKHVKNHALRNANGQLRRKSAGGASVPPSGPKK 612
            ||||| |||.:.|||.|::||||||||||||||||||  .:......:.:|..|.|...|..||.
Zfish   515 RAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVK--TVHGPEAHVTKKQRGDAPPKPHPPKG 577

  Fly   613 AAKTRRHSESALVQRGVGAGVGVAVPSAPGDQRQHRSNSCSEALLLQQHQQQQQQQQQQQKQHQP 677
            ..:...|::..   ||...|.|.|             ||.:..:...||.:..:.:.....|..|
Zfish   578 NGENEAHTKHV---RGRTDGSGEA-------------NSTTRGVEDCQHVKTIKTENTVMYQSSP 626

  Fly   678 ENERTTDRSNCGTGVAANNNSMNFNELSNCIVIIEHNQSGGPAGPATLATATATTTATATYGNG- 741
            ..:.:........|.|.||:|        .:.:..|  |||..|..:....|....:|.:.|..
Zfish   627 GGQSSCSSEPSPLGSATNNDS--------GVEMAMH--SGGSLGDLSALDDTPVVDSTGSPGTSA 681

  Fly   742 --------NMAPAPETE---------VLSVCSGGGSSNSNSNNNRYNANINQLSELEQLLTTAKP 789
                    |.|...:.|         |...||.     :|:.....|..:..:..::.|| .|..
Zfish   682 GVGLQLRKNRAGLLQLEHIKKEKLKTVRDSCSW-----ANAPPQVRNTKLPPIPSIDSLL-DAPN 740

  Fly   790 TGTPA---------------------------ASANGISLANNNGRANGDSKCHLS 818
            .||..                           :|.:.:|.|..:.|::|.|.|:.|
Zfish   741 MGTQMSVPPTQHLGDLSSYEMTMLNQLHERRDSSTSTMSSAYISRRSSGISPCYSS 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	SFP1	<493..585	CDD:227516	69/92 (75%)
		C2H2 Zn finger	504..526	CDD:275368	15/21 (71%)
		C2H2 Zn finger	534..556	CDD:275368	16/22 (73%)
		C2H2 Zn finger	564..586	CDD:275368	19/21 (90%)
gli2a	NP_571042.1	C2H2 Zn finger	441..462	CDD:275368	11/20 (55%)
		zf-H2C2_2	454..481	CDD:463886	16/26 (62%)
		C2H2 Zn finger	470..492	CDD:275368	15/21 (71%)
		zf-H2C2_2	484..511	CDD:463886	18/26 (69%)
		SFP1	<494..554	CDD:227516	44/61 (72%)
		C2H2 Zn finger	500..523	CDD:275368	16/22 (73%)
		C2H2 Zn finger	531..552	CDD:275368	19/22 (86%)