DRSC/TRiP Functional Genomics Resources

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Protein Alignment lmd and GLI3

DIOPT Version :10

Sequence 1:NP_732811.1 Gene:lmd / 42717 FlyBaseID:FBgn0039039 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_000159.3 Gene:GLI3 / 2737 HGNCID:4319 Length:1580 Species:Homo sapiens


Alignment Length:805 Identity:214/805 - (26%)
Similarity:324/805 - (40%) Gaps:193/805 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 NREDIFRFEPEDIARLTGESELPGMLQHPQTPYTPYTPYTPYTPCSAQNSQYAVQPANDSINLDI 199
            :.|..:.::|..|..|...|.|.....:|..|:...:|:.  .|.:|..|.::  |.:..||..:
Human   141 HHEGRYHYDPSPIPPLHMTSALSSSPTYPDLPFIRISPHR--NPTAASESPFS--PPHPYINPYM 201

  Fly   200 DYF-------NYDEINCQSKNQSPCSSPHLDA-------WLNFNLGEISAAAS--SSAASPKLGN 248
            ||.       :...|:. ::..||..:||...       .:....|:.|..|.  .|||:...|.
Human   202 DYIRSLHSSPSLSMISA-TRGLSPTDAPHAGVSPAEYYHQMALLTGQRSPYADIIPSAATAGTGA 265

  Fly   249 VFEEQVKEEASPAKLPSMNST-FGTPKCI-------PMCASNYEDYANLYQQGSGYSTENYHNNM 305
            :..|.         |.:|:|| |.:|:..       .:..|...|::...|.    ......|::
Human   266 IHMEY---------LHAMDSTRFSSPRLSARPSRKRTLSISPLSDHSFDLQT----MIRTSPNSL 317

  Fly   306 AQVVEKPNREHKAIWTIDELDELMLGEQQQF------LQHHLQQQHLQEQQEQ----LHQP---- 356
            ..::........|..:...|....:.....|      :..|:.||.|..||..    .|.|    
Human   318 VTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSLHMHQQILSRQQSLGSAFGHSPPLIH 382

  Fly   357 ------------------------HGQEQQTQNCKDDLVNYLSDEFIKAEEFRSLDSDDDENYNE 397
                                    .|..:.:||              |.....::.|..|..:|:
Human   383 PAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQN--------------KPTSESAVSSTGDPMHNK 433

  Fly   398 EED-DLDNDVFAPPAE-SDPKPDSTCC------DPEAEPENEVI-PLICRWTGCDEEFPHQQAFV 453
            ... ..|.|:.:|.|. ...:|:.|..      ..|::.|.||| ...|.|.||..||..|:..|
Human   434 RSKIKPDEDLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYETNCHWEGCAREFDTQEQLV 498

  Fly   454 EHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLEN 518
            .||...|:...| ::|.|.||||.|..|||.|:|.|::|||.|:||||:||.|.||.||:|||||
Human   499 HHINNDHIHGEK-KEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLEN 562

  Fly   519 LKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKPYACQLPGCTKRYTDPSSLRKH 582
            ||.|.||||||:||.|:::||.|||||:||||||| |||.:.|||.|::||||||||||||||||
Human   563 LKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKH 627

  Fly   583 VKNHALRNANGQLRRKSAGGASVPPSGPKKAAKTRRHSESALVQRGVGAGVGVAVPSAPGDQRQH 647
            ||  .:......:.:|..|.....|..|:.:..   ||:|....|.....:|         ::|.
Human   628 VK--TVHGPEAHVTKKQRGDIHPRPPPPRDSGS---HSQSRSPGRPTQGALG---------EQQD 678

  Fly   648 RSNSCSEALLLQQHQQQQQQQQQQQKQHQPENERTTDRSNCGTGVAANNNS--MNFNELSNCIVI 710
            .||:.|           ::::..|.|..:.|...|:..|..|....::..|  .|::.....:.:
Human   679 LSNTTS-----------KREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYSNSGLELPL 732

  Fly   711 IEHNQSGGPAG--------PATLATATATTTATATYGNGNMAPA--------------------- 746
            .:    ||..|        |...:|.:..|||.|.....|.|..                     
Human   733 TD----GGSIGDLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVKLERLKQVNGMFPRL 793

  Fly   747 -----PETEVLSVCSGGGSSNSNS------------NNNRYNANINQLSELEQLLTTAKPTGTPA 794
                 |:...:|...|.|:.::|:            .::....::..|:.|.:          ..
Human   794 NPILPPKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVTMLNMLNR----------RD 848

  Fly   795 ASANGISLAN-NNGRANGDSKCHLS 818
            :||:.||.|. ::.|::|.|.|..|
Human   849 SSASTISSAYLSSRRSSGISPCFSS 873

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lmdNP_732811.1 SFP1 <493..585 CDD:227516 69/92 (75%)
C2H2 Zn finger 504..526 CDD:275368 15/21 (71%)
C2H2 Zn finger 534..556 CDD:275368 16/22 (73%)
C2H2 Zn finger 564..586 CDD:275368 19/21 (90%)
GLI3NP_000159.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 368..475 18/120 (15%)
SFP1 <542..632 CDD:227516 67/91 (74%)
C2H2 Zn finger 548..570 CDD:275368 15/21 (71%)
C2H2 Zn finger 578..601 CDD:275368 16/22 (73%)
C2H2 Zn finger 609..630 CDD:275368 19/22 (86%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 620..728 31/132 (23%)
Mediates interaction with DZIP1. /evidence=ECO:0000250|UniProtKB:Q61602 745..845 14/99 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..918 5/11 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 981..1042
Blue background indicates that the domain is not in the aligned region.

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