DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lmd and GLI3

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_000159.3	Gene:	GLI3 / 2737	HGNCID:	4319	Length:	1580	Species:	Homo sapiens

Alignment Length:	805	Identity:	214/805 - (26%)
Similarity:	324/805 - (40%)	Gaps:	193/805 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 NREDIFRFEPEDIARLTGESELPGMLQHPQTPYTPYTPYTPYTPCSAQNSQYAVQPANDSINLDI 199
            :.|..:.::|..|..|...|.|.....:|..|:...:|:.  .|.:|..|.::  |.:..||..:
Human   141 HHEGRYHYDPSPIPPLHMTSALSSSPTYPDLPFIRISPHR--NPTAASESPFS--PPHPYINPYM 201

  Fly   200 DYF-------NYDEINCQSKNQSPCSSPHLDA-------WLNFNLGEISAAAS--SSAASPKLGN 248
            ||.       :...|:. ::..||..:||...       .:....|:.|..|.  .|||:...|.
Human   202 DYIRSLHSSPSLSMISA-TRGLSPTDAPHAGVSPAEYYHQMALLTGQRSPYADIIPSAATAGTGA 265

  Fly   249 VFEEQVKEEASPAKLPSMNST-FGTPKCI-------PMCASNYEDYANLYQQGSGYSTENYHNNM 305
            :..|.         |.:|:|| |.:|:..       .:..|...|::...|.    ......|::
Human   266 IHMEY---------LHAMDSTRFSSPRLSARPSRKRTLSISPLSDHSFDLQT----MIRTSPNSL 317

  Fly   306 AQVVEKPNREHKAIWTIDELDELMLGEQQQF------LQHHLQQQHLQEQQEQ----LHQP---- 356
            ..::........|..:...|....:.....|      :..|:.||.|..||..    .|.|
Human   318 VTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSLHMHQQILSRQQSLGSAFGHSPPLIH 382

  Fly   357 ------------------------HGQEQQTQNCKDDLVNYLSDEFIKAEEFRSLDSDDDENYNE 397
                                    .|..:.:||              |.....::.|..|..:|:
Human   383 PAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQN--------------KPTSESAVSSTGDPMHNK 433

  Fly   398 EED-DLDNDVFAPPAE-SDPKPDSTCC------DPEAEPENEVI-PLICRWTGCDEEFPHQQAFV 453
            ... ..|.|:.:|.|. ...:|:.|..      ..|::.|.||| ...|.|.||..||..|:..|
Human   434 RSKIKPDEDLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYETNCHWEGCAREFDTQEQLV 498

  Fly   454 EHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLEN 518
            .||...|:...| ::|.|.||||.|..|||.|:|.|::|||.|:||||:||.|.||.||:|||||
Human   499 HHINNDHIHGEK-KEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLEN 562

  Fly   519 LKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKPYACQLPGCTKRYTDPSSLRKH 582
            ||.|.||||||:||.|:::||.|||||:||||||| |||.:.|||.|::||||||||||||||||
Human   563 LKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKH 627

  Fly   583 VKNHALRNANGQLRRKSAGGASVPPSGPKKAAKTRRHSESALVQRGVGAGVGVAVPSAPGDQRQH 647
            ||  .:......:.:|..|.....|..|:.:..   ||:|....|.....:|         ::|.
Human   628 VK--TVHGPEAHVTKKQRGDIHPRPPPPRDSGS---HSQSRSPGRPTQGALG---------EQQD 678

  Fly   648 RSNSCSEALLLQQHQQQQQQQQQQQKQHQPENERTTDRSNCGTGVAANNNS--MNFNELSNCIVI 710
            .||:.|           ::::..|.|..:.|...|:..|..|....::..|  .|::.....:.:
Human   679 LSNTTS-----------KREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYSNSGLELPL 732

  Fly   711 IEHNQSGGPAG--------PATLATATATTTATATYGNGNMAPA--------------------- 746
            .:    ||..|        |...:|.:..|||.|.....|.|..
Human   733 TD----GGSIGDLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVKLERLKQVNGMFPRL 793

  Fly   747 -----PETEVLSVCSGGGSSNSNS------------NNNRYNANINQLSELEQLLTTAKPTGTPA 794
                 |:...:|...|.|:.::|:            .::....::..|:.|.:          ..
Human   794 NPILPPKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVTMLNMLNR----------RD 848

  Fly   795 ASANGISLAN-NNGRANGDSKCHLS 818
            :||:.||.|. ::.|::|.|.|..|
Human   849 SSASTISSAYLSSRRSSGISPCFSS 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	16/25 (64%)
		C2H2 Zn finger	504..526	CDD:275368	15/21 (71%)
		C2H2 Zn finger	534..556	CDD:275368	16/22 (73%)
		C2H2 Zn finger	564..586	CDD:275368	19/21 (90%)
GLI3	NP_000159.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..475		18/120 (15%)
		zf-H2C2_2	532..559	CDD:290200	16/26 (62%)
		C2H2 Zn finger	548..570	CDD:275368	15/21 (71%)
		zf-H2C2_2	562..589	CDD:290200	18/26 (69%)
		C2H2 Zn finger	578..601	CDD:275368	16/22 (73%)
		C2H2 Zn finger	609..630	CDD:275368	19/22 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..728		31/132 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..918		5/11 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	981..1042
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940