Protein Alignment lmd and GLI2

DIOPT Version :9

• Sequence 1: NP_732811.1
• Gene: lmd / 42717
• FlyBaseID: FBgn0039039
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: XP_011509271.2
• Gene: GLI2 / 2736
• HGNCID: 4318
• Length: 1670
• Species: Homo sapiens
• Alignment Length: 838
• Identity: 213/838 - (25%)
• Similarity: 296/838 - (35%)
• Gaps: 276/838 - (32%)

  Fly   124 MPYQQGQYTQLNREDIFRFEPEDIARLTGESELPG-----------MLQHPQTP-YTPYTPYTPY 176
            |.:|:|:|         .:||..:..:.|...|.|           :..||..| .:|:....||
Human   150 MRHQEGRY---------HYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHPY 205

  Fly   177 TPCSAQNSQYAVQPANDSINLDIDYFNYDEINCQSKNQSPCSSPHLDAWLNFNLGEISAAASSSA 241
                              :|..::::      .:|.:.||            .|..||||...|.
Human   206 ------------------VNPHMEHY------LRSVHSSP------------TLSMISAARGLSP 234

  Fly   242 ASPKLGNVFEEQVKEEA-----SPAKLPS-----MNSTFGTPKCIPMCASNYEDYANLYQQGSGY 296
            |     :|.:|.:||..     :|...||     |....|.|       :.|.|.  |.|.|...
Human   235 A-----DVAQEHLKERGLFGLPAPGTTPSDYYHQMTLVAGHP-------APYGDL--LMQSGGAA 285

  Fly   297 STENYHNNMAQV-VEK-------PNREHKAIWTIDELDELMLGEQQQ----------FLQH---- 339
            |..:.|:.:..| |.:       |....|...:|..|.:..|..|:.          ::.:
Human   286 SAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSRSS 350

  Fly   340 --------HLQ------------------QQHLQEQQEQLHQPHG-------------------- 358
                    ||.                  .|.:..||..|....|
Human   351 SAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQRGLGSAFGHTPPLIQPSPTFLAQQPMAL 415

  Fly   359 --------QEQQTQNCKDDL-VNYLSDEFIKAEEFRSLDSDDDENYNEEEDDLDNDVFAPPAE-- 412
                    |...:.||..|. .|..|.|...:.....:..........|.:.|      .||.
Human   416 TSINATPTQLSSSSNCLSDTNQNKQSSESAVSSTVNPVAIHKRSKVKTEPEGL------RPASPL 474

  Fly   413 ------------------------SDPKPDSTCCDPEAEPENEVIPLICRWTGCDEEFPHQQAFV 453
                                    :|.|.|....|.:.|.|..:....|.|..|.:|:..|:..|
Human   475 ALTQGQVSGHGSCGCALPLSQEQLADLKEDLDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLV 539

  Fly   454 EHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLEN 518
            .||...|:...| ::|.|.|..|.|..|||.|:|.|::|||.|:||||:||.|.||:||:|||||
Human   540 HHINNEHIHGEK-KEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLEN 603

  Fly   519 LKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKPYACQLPGCTKRYTDPSSLRKH 582
            ||.|.||||||:||.|:::||.|||||:||||||| |||.:.|||.|::||||||||||||||||
Human   604 LKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKH 668

  Fly   583 VKN------HALRNANGQ-------LRRKSAGGASVPPSGPK--KAAKTRRHSESALVQRGVGAG 632
            ||.      |..:.....       |:......|...|.||:  :|:.|.:..|..|..|.:...
Human   669 VKTVHGPDAHVTKKQRNDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTE 733

  Fly   633 VGVAVPSAPGDQRQHRSNSCSEALLLQQHQQQQQQQQQQQKQHQPENERTTDRSNCGTGVAANNN 697
            ......|:||.|     :|||.                     :|.          ..|.|.||:
Human   734 SSGLCQSSPGAQ-----SSCSS---------------------EPS----------PLGSAPNND 762

  Fly   698 SMNFNELSNCIVIIEHNQSGGPAGPATLATATATTTATATYGNGNMAPAPETEVLSVCSGGG--- 759
            |               .......||.:|...||.         .:..|..:|..|:..|.||
Human   763 S---------------GVEMPGTGPGSLGDLTAL---------DDTPPGADTSALAAPSAGGLQL 803

  Fly   760 SSNSNSNNNRYNANINQLSELEQLLTTAKP------TGTPAASANGISLANNNGRANG 811
            ..:..:.:........:|..|:...:.|.|      |..|....:|..|.|.:|...|
Human   804 RKHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSGGG 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	16/25 (64%)
		C2H2 Zn finger	504..526	CDD:275368	15/21 (71%)
		C2H2 Zn finger	534..556	CDD:275368	16/22 (73%)
		C2H2 Zn finger	564..586	CDD:275368	19/27 (70%)
GLI2	XP_011509271.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940