Protein Alignment lmd and Zic2

DIOPT Version :10

• Sequence 1: NP_732811.1
• Gene: lmd / 42717
• FlyBaseID: FBgn0039039
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_033600.3
• Gene: Zic2 / 22772
• MGIID: 106679
• Length: 529
• Species: Mus musculus
• Alignment Length: 613
• Identity: 152/613 - (24%)
• Similarity: 218/613 - (35%)
• Gaps: 214/613 - (34%)

  Fly   213 NQSPCSSPHLDAWLNFNLGEISAAASSSAASPKLGNVFEEQVKEEASPAKLPSMNSTFGTPKCIP 277
            :|.|.:.|          |..:|||:::|..|...:|         .....|..|||    :...
Mouse    79 SQGPGAYP----------GSAAAAAAAAALGPHAAHV---------GSYSGPPFNST----RDFL 120

  Fly   278 MCASNYEDYA------NLYQQGSGYSTENYHNNMAQVVEKPNREHKAIWTIDELDELMLGEQQQF 336
            ..:..:.|.|      .|:..|:| ...:.|::
Mouse   121 FRSRGFGDSAPGGGQHGLFGPGAG-GLHHAHSD-------------------------------- 152

  Fly   337 LQHHLQQQHLQEQQEQLHQPHGQEQQTQNCKDDLVNYLSDE---------FIKAEEFRSLDSDDD 392
            .|.||....|.||    |.||..:           |.|:.:         |.::|::|.:.|...
Mouse   153 AQGHLLFPGLPEQ----HGPHASQ-----------NVLNGQMRLGLPGEVFGRSEQYRQVASPRT 202

  Fly   393 ENYNEEEDDLDNDVFAP----------------------PAESDPKPDSTCCDPEAEPENEVIPL 435
            :.|:..:  |.|. :.|                      |..........|...|         |
Mouse   203 DPYSAAQ--LHNQ-YGPMNMNMGMNMAAAAAHHHHHHHHPGAFFRYMRQQCIKQE---------L 255

  Fly   436 ICRW----------TGCDEEFPHQQAFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLL 490
            ||:|          ..|::.|......|.|:...||...:..:..|||.:|||..|||.|:|||:
Mouse   256 ICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLV 320

  Fly   491 IHMRVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRT 555
            .|:|||:||||..||||||.|.|:|.||||||:|:||||:|:.|:::||.:.|:|||||.||...
Mouse   321 NHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHV 385

  Fly   556 HYDTKPYACQLPGCTKRYTDPSSLRKHVKNHALRNANGQLRRKSAGG--ASVPPSGPKKAAKTRR 618
            |...|||.|::  |.|.||.|||||||:|.|.......:....::.|  :|.||.....:|:.:.
Mouse   386 HTSDKPYLCKM--CDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQS 448

  Fly   619 HSESALVQRGVGAGVGVAVPSAPGDQRQHRSNSCSEALLLQQHQQQQQQQQQQQKQHQPENERTT 683
            .|..:.......|....|..:.....|...|.|
Mouse   449 SSNLSPAAAAAAAAAAAAAAAVSAVHRGAGSGS-------------------------------- 481

  Fly   684 DRSNCGTGVAANNNSMNFNELSNCIVIIEHNQSGGPAGPATLATATATTTATATYGNGNMAPAPE 748
              |..|.|.||.                    |||..|.|               |.|...
Mouse   482 --SGSGGGSAAG--------------------SGGGGGGA---------------GGGGGG---- 505

  Fly   749 TEVLSVCSGGGSSNSNSNNNRYNANINQ 776
                   |.||.|.:...::..::|.|:
Mouse   506 -------SSGGGSGTTGGHSGLSSNFNE 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	SFP1	<493..585	CDD:227516	55/91 (60%)
		C2H2 Zn finger	504..526	CDD:275368	16/21 (76%)
		C2H2 Zn finger	534..556	CDD:275368	11/21 (52%)
		C2H2 Zn finger	564..586	CDD:275368	13/21 (62%)
Zic2	NP_033600.3	zf_ZIC	249..294	CDD:436441	12/53 (23%)
		C2H2 Zn finger	306..326	CDD:275368	12/19 (63%)
		SFP1	<328..412	CDD:227516	52/85 (61%)
		C2H2 Zn finger	334..356	CDD:275368	16/21 (76%)
		C2H2 Zn finger	364..386	CDD:275368	11/21 (52%)
		C2H2 Zn finger	394..414	CDD:275368	13/21 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..451		13/45 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..529		21/132 (16%)