DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lmd and ztf-14

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001360586.1	Gene:	ztf-14 / 187492	WormBaseID:	WBGene00010936	Length:	483	Species:	Caenorhabditis elegans

Alignment Length:	463	Identity:	119/463 - (25%)
Similarity:	171/463 - (36%)	Gaps:	138/463 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 PYTPYTPCSAQNSQYAVQPANDSINLDIDYFNYDEINCQSKNQSPCSSPHLDAWLNFNLGEISAA 236
            ||......:.|||      .|.|.:|    .||       .:.||.||.....   :|..|:|..
Worm    16 PYPNALDVTHQNS------GNSSPSL----HNY-------SSMSPASSVSNTV---YNSSEVSPM 60

  Fly   237 ASSSAASPKLGNVFEEQVKEE---ASPAKLPSMNSTFGTPKCIPMCASNYEDYANLYQQGSGYST 298
            .:..|:..|..|.||....:.   .:|...|.:.:.|.:|      ||:..:..|....||.
Worm    61 GTGDASWNKAPNYFERPKPDRHIVLNPLGSPDIGAQFQSP------ASSIMNTINSLVHGSS--- 116

  Fly   299 ENYHNNMAQVVEKPNREHKAIWTIDELDELMLGEQQQFLQHHLQQQHLQEQQEQLHQPHGQEQQT 363
                ..:.||                       :|.|:...       .|....|.:||.....|
Worm   117 ----GGLLQV-----------------------QQSQYFGP-------AELNPNLKRPHDATTST 147

  Fly   364 Q-----------NCKDDLVNYLSDEFIKAEEFRSLDSDDDENYNEEEDDLDNDVFAPPAESDP-- 415
            :           :|.......       .:..|.:.::..|..:||     .||..|  :..|
Worm   148 EFGALSVVPIPFDCNQTTGGI-------EQTIREVATNKRERVDEE-----LDVIIP--KKQPRL 198

  Fly   416 --------KPDSTCCDPEAEP-----ENEVIPLICRWTGCDEEFPHQQAFVEHIEKCHVDVRKGE 467
                    :|..:|......|     :|:.....|.|.||......:..|..|::.   .::|.|
Worm   199 SVNGKRIGRPPGSCKANYIPPTKITEQNDEDVRQCLWDGCTLTLDDRATFFVHVDN---HIQKNE 260

  Fly   468 DFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPY 532
            ..|                     |.|.|:.:|...|..  |.|.:.||||||.|:|:||||:||
Worm   261 VNS---------------------HKRTHTKQKLYCCEV--CPKRYGRLENLKTHRRTHTGEKPY 302

  Fly   533 GCQYKGCLKAFSNSSDRAKH-QRTHYDTKPYACQLPGCTKRYTDPSSLRKHVK-----NHALRNA 591
            .|....|.|:|:|:|||:|| :|||.:.|||.|....|...||||||||||||     :||::.|
Worm   303 HCNVPNCNKSFTNASDRSKHSKRTHSNEKPYCCDFGSCACAYTDPSSLRKHVKSKHPEHHAMKMA 367

  Fly   592 NGQLRRKS 599
            ..:.:|||
Worm   368 MRKTQRKS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	7/25 (28%)
		C2H2 Zn finger	504..526	CDD:275368	11/21 (52%)
		C2H2 Zn finger	534..556	CDD:275368	11/22 (50%)
		C2H2 Zn finger	564..586	CDD:275368	14/26 (54%)
ztf-14	NP_001360586.1	zf-H2C2_2	260..285	CDD:372612	9/47 (19%)
		zf-C2H2	274..296	CDD:333835	11/23 (48%)
		C2H2 Zn finger	276..296	CDD:275368	11/21 (52%)
		zf-H2C2_2	288..315	CDD:372612	15/26 (58%)
		SFP1	<298..358	CDD:227516	34/59 (58%)
		C2H2 Zn finger	304..327	CDD:275368	11/22 (50%)
		C2H2 Zn finger	335..355	CDD:275368	12/19 (63%)
		VI_FHA	<388..>478	CDD:274537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159309
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840