DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lmd and tra-1

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001022880.2	Gene:	tra-1 / 176548	WormBaseID:	WBGene00006604	Length:	1110	Species:	Caenorhabditis elegans

Alignment Length:	385	Identity:	133/385 - (34%)
Similarity:	181/385 - (47%)	Gaps:	92/385 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 LICRWTGCDEEFPHQQAFVEHIEKCHVDVRKGED--FSCFWLDCPRRYKPFNARYKLLIHMRVHS 497
            |.|||..|:..|...:|.|:|:::.||...:.|.  :.|.|..|.|. :.|.|.|.|::|:|.|:
Worm   208 LTCRWKSCNSSFQTLKALVDHVQESHVQSTEQEHHAWRCEWEGCDRN-ETFKALYMLIVHVRRHT 271

  Fly   498 GEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKP 561
            |||||||.:|||.|.:|||||||.|:|:||||:||.|::..|.|||||:||||||| |||.:.||
Worm   272 GEKPNKCEYPGCGKEYSRLENLKTHRRTHTGEKPYKCEFADCEKAFSNASDRAKHQNRTHSNLKP 336

  Fly   562 YACQLPGCTKRYTDPSSLRKHVKN-HA---------LRNANGQLRRKSAGGASVPPSG------- 609
            |:||:|.|||.||||||||||:|. |.         .|.||...||: ......||:|
Worm   337 YSCQIPQCTKSYTDPSSLRKHIKAVHGDDEYEKAKKSRPANYSNRRR-PDHRLAPPTGAMSHPYL 400

  Fly   610 --PKKAAKTRRHS--------ESALVQR------------GVGAGVGVAVPSAPGDQRQHRSNSC 652
              |...|....||        ..||.|.            ..|..:.:..|::.....|.:::..
Worm   401 ATPNSGASVVAHSSVHQQNFINMALAQHHHNAQRAQQLMAATGNVMPMMDPASAAAAAQAQAHHQ 465

  Fly   653 SEALLLQQHQQQQQQ-----QQQQQKQHQPENERTTDRSNCGTGVAANNNSMNFNELSNCIVIIE 712
            ::|.:||.|..||.|     |.|.|.|||.                    :|..:.:....::::
Worm   466 AQAQMLQTHMMQQAQIQAAAQMQAQVQHQA--------------------AMQAHAMQQAQMVLQ 510

  Fly   713 HNQSGG-----------PAGPATLATATATTTATATYGNGNMAP--------APETEVLS 753
            :|..|.           |...|....|...|..|.|    ::||        ||...|:|
Worm   511 NNLLGAQSLLSPFSPLLPPSRAPNVMAMLQTPPTPT----SVAPMFDIMTSRAPMAPVVS 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	15/25 (60%)
		C2H2 Zn finger	504..526	CDD:275368	14/21 (67%)
		C2H2 Zn finger	534..556	CDD:275368	15/22 (68%)
		C2H2 Zn finger	564..586	CDD:275368	17/22 (77%)
tra-1	NP_001022880.2	COG5048	<177..358	CDD:227381	84/150 (56%)
		C2H2 Zn finger	246..270	CDD:275368	10/24 (42%)
		SFP1	<272..362	CDD:227516	63/89 (71%)
		C2H2 Zn finger	278..300	CDD:275368	14/21 (67%)
		zf-H2C2_2	292..319	CDD:316026	16/26 (62%)
		C2H2 Zn finger	308..331	CDD:275368	15/22 (68%)
		C2H2 Zn finger	339..362	CDD:275368	17/22 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I8021
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3867
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19818
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.990