DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lmd and GLIS3

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001035878.1	Gene:	GLIS3 / 169792	HGNCID:	28510	Length:	930	Species:	Homo sapiens

Alignment Length:	751	Identity:	229/751 - (30%)
Similarity:	288/751 - (38%)	Gaps:	210/751 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GFMSPPLSANITANNG-----EREMFRVPGAKVETNESYACGELQFP--DFSHLCFAAETPNSVF 94
            |.:|||.|...||.|.     :|.|              ....|..|  |...|.......::..
Human   162 GLISPPASQVSTACNQISPSLQRAM--------------NAANLNIPPSDTRSLISRESLASTTL 212

  Fly    95 SDCHNYAGQDQQQDSDQDDIVCAAAENTGMPYQQGQYTQLNREDIFRFEP-EDIARLTGESELPG 158
            |...:.:....:|:..|......:..|.|.  |.|    |:..|:....| ..::..:..:.||.
Human   213 SLTESQSASSMKQEWSQGYRALPSLSNHGS--QNG----LDLGDLLSLPPGTSMSSNSVSNSLPS 271

  Fly   159 MLQHPQTPYTPY-TPYTPYTPCSAQNSQ---YAVQPANDSINLDIDYFNYDEINCQSKNQSPCSS 219
            .|...::.::|| :|....|...:..|:   .::.|.:|.|.:|   ||      .....||.|
Human   272 YLFGTESSHSPYPSPRHSSTRSHSARSKKRALSLSPLSDGIGID---FN------TIIRTSPTS- 326

  Fly   220 PHLDAWLNFNLGEISAAASSSAASPKLGNVFEEQVKEEASPAKLPSMNSTFG-----TPKCIPMC 279
              |.|::|                           ...||||.|......:|     ...|||..
Human   327 --LVAYIN---------------------------GSRASPANLSPQPEVYGHFLGVRGSCIPQP 362

  Fly   280 ASNYEDYANLYQQGSGYSTENYHNNMAQVVEKPNREHKAIWTIDELDELMLGEQQQFLQHHLQQQ 344
            .........:.....|.:...|..:.|       .||      :.:.:|..|..|..|.:|:..|
Human   363 RPVPGSQKGVLVAPGGLALPAYGEDGA-------LEH------ERMQQLEHGGLQPGLVNHMVVQ 414

  Fly   345 HLQEQQEQLHQPHGQEQQTQNCKDDLVNYLSDEFIKAEEFRSLDSDDDENYNEEEDDLDNDVFAP 409
            |      .|..|..|               |....|.|..        |.:.....||......|
Human   415 H------GLPGPDSQ---------------SAGLFKTERL--------EEFPGSTVDLPPAPPLP 450

  Fly   410 PAESDPKP------DSTCCDPEAEPENEVIPL------------------ICRWTGCDEEFPHQQ 450
            |....|.|      .:....||..|..:.:.|                  .|||..|...:..|:
Human   451 PLPPPPGPPPPYHAHAHLHHPELGPHAQQLALPQATLDDDGEMDGIGGKHCCRWIDCSALYDQQE 515

  Fly   451 AFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSR 515
            ..|.||||.|:|.||||||:|||..|||||||||||||||||||||||||||||.|.||.|||||
Human   516 ELVRHIEKVHIDQRKGEDFTCFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCEKAFSR 580

  Fly   516 LENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRTHYDTKPYACQLPGCTKRYTDPSSLR 580
            |||||||.||||||:||.||:.||.||||||||||||||||.||||||||:||||||||||||||
Human   581 LENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLR 645

  Fly   581 KHVKNHALR-------------------------------------------------------- 589
            ||||.|:.:
Human   646 KHVKAHSSKEQQARKKLRSSTELHPDLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSA 710

  Fly   590 ---NANGQLRRKSAGGASVPP-----SGPKKAAKTRRHSESALVQ--RGVGAGVGVAVPSAPGDQ 644
               ::|...|..:|.||..||     ..|....:...|:.|:.:.  ..|.||.....||||...
Human   711 PIFSSNYSSRSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAVDAGAERFAPSAPSPH 775

  Fly   645 R--QHRSNSCSEALLLQQHQQQQQQQQQQQKQHQPE 678
            .  ..|..:.|..|...|....||......|.:|||
Human   776 HISPRRVPAPSSILQRTQPPYTQQPSGSHLKSYQPE 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	22/25 (88%)
		C2H2 Zn finger	504..526	CDD:275368	17/21 (81%)
		C2H2 Zn finger	534..556	CDD:275368	18/21 (86%)
		C2H2 Zn finger	564..586	CDD:275368	20/21 (95%)
GLIS3	NP_001035878.1	zf-H2C2_2	554..580	CDD:290200	22/25 (88%)
		C2H2 Zn finger	569..591	CDD:275368	17/21 (81%)
		zf-H2C2_2	583..610	CDD:290200	20/26 (77%)
		C2H2 Zn finger	599..621	CDD:275368	18/21 (86%)
		C2H2 Zn finger	629..651	CDD:275368	20/21 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9850
eggNOG	1	0.900	-	-		E33208_3BAZE
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3867
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40893
orthoMCL	1	0.900	-	-		OOG6_109660
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	1	1.000	-	-		X3347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.740