Protein Alignment lmd and ZXDB

DIOPT Version :9

• Sequence 1: NP_732811.1
• Gene: lmd / 42717
• FlyBaseID: FBgn0039039
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_009088.1
• Gene: ZXDB / 158586
• HGNCID: 13199
• Length: 803
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 96/387 - (24%)
• Similarity: 148/387 - (38%)
• Gaps: 92/387 - (23%)

  Fly   427 EPENEVIPLICRWTGCDEEFPHQQAFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLI 491
            |||.   |..|.::||.:.|....|...| .:.|  .|:.|.|||.:..|.::|   :...:|.|
Human   388 EPER---PYQCAFSGCKKTFITVSALFSH-NRAH--FREQELFSCSFPGCSKQY---DKACRLKI 443

  Fly   492 HMRVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRTH 556
            |:|.|:||:|..|.|.||...|:.:..|..|:|.|..:|.:.|..:||.|:|:.:.....|..||
Human   444 HLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITH 508

  Fly   557 YDTKPYACQLPGCTKRYTDPSSLRKHVKNHALRNANGQLRRKSAGGASVPPSGPKKAAKTRRHSE 621
            ..|||:.|.:.||..|::..|||..|.|.|        |:......:..|.|...|.. |.:||
Human   509 LGTKPFVCPVAGCCARFSARSSLYIHSKKH--------LQDVDTWKSRCPISSCNKLF-TSKHS- 563

  Fly   622 SALVQRGVGAGVGVAVPSAPGDQRQHRSNSCSEALLLQQHQQQQQQQQQQQKQHQ--PENERTTD 684
                                  .:.|         ::::|:..|....|.:..:.  |.:|.|:.
Human   564 ----------------------MKTH---------MVKRHKVGQDLLAQLEAANSLTPSSELTSQ 597

  Fly   685 RSNCGTGVAANNNSMNFNELSNCIVIIEHNQSGGPAGPATLATATATTTATATYGNGNMAPAPET 749
            |.               |:||:..::...:........|.|.||..         |..:......
Human   598 RQ---------------NDLSDAEIVSLFSDVPDSTSAALLDTALV---------NSGILTIDVA 638

  Fly   750 EVLSVCSGGGSSNSNSNNNRYNANINQLSELEQLLTTAKPT---------GTPAASANGISL 802
            .|.|..:|...:|   |||    ::.|..:...|:.|:.|.         ||.|......||
Human   639 SVSSTLAGHLPAN---NNN----SVGQAVDPPSLMATSDPPQSLDTSLFFGTAATGFQQSSL 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	13/25 (52%)
		C2H2 Zn finger	504..526	CDD:275368	8/21 (38%)
		C2H2 Zn finger	534..556	CDD:275368	6/21 (29%)
		C2H2 Zn finger	564..586	CDD:275368	9/21 (43%)
ZXDB	NP_009088.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..91
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..140
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..260
		Required for interaction with ZXDC. /evidence=ECO:0000250	271..577		66/238 (28%)
		C2H2 Zn finger	273..295	CDD:275368
		zf-C2H2_aberr	304..449	CDD:293622	22/69 (32%)
		zf-C2H2	304..328	CDD:278523
		C2H2 Zn finger	306..328	CDD:275368
		C2H2 Zn finger	336..358	CDD:275368
		zf-H2C2_2	350..373	CDD:290200
		zf-C2H2	364..386	CDD:278523
		C2H2 Zn finger	366..386	CDD:275368
		C2H2 Zn finger	395..417	CDD:275368	6/22 (27%)
		C2H2 Zn finger	429..448	CDD:275368	6/21 (29%)
		COG5048	<441..572	CDD:227381	47/171 (27%)
		C2H2 Zn finger	456..478	CDD:275368	8/21 (38%)
		zf-H2C2_2	471..497	CDD:290200	10/25 (40%)
		C2H2 Zn finger	486..508	CDD:275368	6/21 (29%)
		C2H2 Zn finger	516..538	CDD:275370	9/21 (43%)
		Required for transcriptional activation. /evidence=ECO:0000250	576..703		30/149 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157355
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840