DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lmd and Gli2

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_036016415.1	Gene:	Gli2 / 14633	MGIID:	95728	Length:	1581	Species:	Mus musculus

Alignment Length:	838	Identity:	216/838 - (25%)
Similarity:	303/838 - (36%)	Gaps:	289/838 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 MPYQQGQYTQLNREDIFRFEPEDIARLTGESELPG-----------MLQHPQTP-YTPYTPYTPY 176
            |.:|:|:|         .::|..:..:.|...|.|           :..||..| .:|::.:.||
Mouse    99 MRHQEGRY---------HYDPHSVHSVHGPPTLSGSPVISDISLIRLSPHPAGPGESPFSAHHPY 154

  Fly   177 TPCSAQNSQYAVQPANDSINLDIDYFNYDEINCQSKNQSPCSSPHLDAWLNFNLGEISAAASSSA 241
                              :|..::::      .:|.:.||            .|..||||...|.
Mouse   155 ------------------VNPHMEHY------LRSVHSSP------------TLSMISAARGLSP 183

  Fly   242 ASPKLGNVFEEQVKEE-----ASPAKLPS-------MNSTFGTPKCIPMCASNYEDYANLYQQGS 294
            |     :|..|.:||.     |:|...||       :.::..||         |.|.  |.|.|.
Mouse   184 A-----DVAHEHLKERGLFSLAAPGTNPSDYYHQMTLMASHPTP---------YGDL--LMQSGG 232

  Fly   295 GYSTENYHNNMAQVVEK--------PNREHKAIWTIDELDELMLGEQQQ----------FLQH-- 339
            ..|..:.|:.:..|...        |....|...:|..|.:..|..|:.          ::.:
Mouse   233 AASAPHLHDYLNPVDASRFSSPRVTPRLSRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSR 297

  Fly   340 ----------HLQ-------------------QQHLQEQQ---------EQLHQPH----GQEQQ 362
                      ||.                   ||.|.:|:         ..|.||.    .|:..
Mouse   298 SSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQRGLGSAFGHTPPLIQPSPTFLAQQPM 362

  Fly   363 T---------------QNCKDD-------------------LVNYLSDEFIKAEEFRSLD--SDD 391
            |               .||.:|                   .::..|....:||..|...  ...
Mouse   363 TLTSISTMPTQLSSSSSNCLNDANQNKQNSESAVSSTVNPITIHKRSKVKTEAEGLRPASPLGLT 427

  Fly   392 DENYNEEEDDLDNDVFAPPAESDPKPDSTCCDPEAEPENEVIPLICRWTGCDEEFPHQQAFVEHI 456
            .|...:.::|||.|                 |.:.|.|..:....|.|..|.:|:..|:..|.||
Mouse   428 QEQLADLKEDLDRD-----------------DCKQEAEVVIYETNCHWADCTKEYDTQEQLVHHI 475

  Fly   457 EKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLENLKI 521
            ...|:...| ::|.|.|..|.|..|||.|:|.|::|||.|:||||:||.|.||:||:|||||||.
Mouse   476 NNEHIHGEK-KEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKT 539

  Fly   522 HQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKPYACQLPGCTKRYTDPSSLRKHVKN 585
            |.||||||:||.|:::||.|||||:||||||| |||.:.|||.|::||||||||||||||||||.
Mouse   540 HLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKT 604

  Fly   586 ------HALRNANGQ-------LRRKSAGGASVPPS--GPK---KAAKTRRHSESALVQRGVGAG 632
                  |..:.....       |:......||..|.  ||:   :|:.|....|..|..:.:...
Mouse   605 VHGPDAHVTKKQRNDVHVRAPLLKENGDNEASAEPGGRGPEESVEASSTSHTVEDCLHIKAIKTE 669

  Fly   633 VGVAVPSAPGDQRQHRSNSCSEALLLQQHQQQQQQQQQQQKQHQPENERTTDRSNCGTGVAANNN 697
            ......|:||.|     :|||.                     :|.          ..|.|.||:
Mouse   670 SSGLCQSSPGAQ-----SSCSS---------------------EPS----------PLGSAPNND 698

  Fly   698 SMNFNELSNCIVIIEHNQSGGPAGPATLATATATTTATATYGNGNMAPAPETEVLSVCSGGGSS- 761
            |               .......||.:|...||.         .:..|..:|..|:..|.||..
Mouse   699 S---------------GMEMPGTGPGSLGDLTAL---------ADTCPGADTSALAAPSTGGLQL 739

  Fly   762 -NSNSNNNRY-NANINQLSELEQLLTTAKP------TGTPAASANGISLANNNGRANG 811
             ...|..:|: .....:|..|:...:.|.|      |..|....||..|.|.|....|
Mouse   740 RKHMSTVHRFEQLKREKLKSLKDSCSWAGPAPHTRNTKLPPLPVNGSVLENFNNTGGG 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	16/25 (64%)
		C2H2 Zn finger	504..526	CDD:275368	15/21 (71%)
		C2H2 Zn finger	534..556	CDD:275368	16/22 (73%)
		C2H2 Zn finger	564..586	CDD:275368	19/27 (70%)
Gli2	XP_036016415.1	SFP1	<516..606	CDD:227516	67/89 (75%)
		C2H2 Zn finger	522..544	CDD:275368	15/21 (71%)
		COG5048	525..>695	CDD:227381	80/205 (39%)
		C2H2 Zn finger	552..575	CDD:275368	16/22 (73%)
		C2H2 Zn finger	583..604	CDD:275368	18/20 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940