DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lmd and Gli1

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_034426.2	Gene:	Gli1 / 14632	MGIID:	95727	Length:	1111	Species:	Mus musculus

Alignment Length:	519	Identity:	161/519 - (31%)
Similarity:	230/519 - (44%)	Gaps:	93/519 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   399 EDDLDNDVFAPPAES---------DPKPDSTCCDPEAEPENE-VIPLICRWTGCDEEFPHQQAFV 453
            ||.|:.|:.:|.:..         |.:.|   .:.|.:||.| |....|||.||.:||..|:..|
Mouse   195 EDPLEGDMSSPNSTGTQDHLLGMLDGRED---LEREEKPEPESVYETDCRWDGCSQEFDSQEQLV 256

  Fly   454 EHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLEN 518
            .||...|:...: ::|.|.|..|.|..:||.|:|.|::|||.|:||||:||.|.||.|::|||||
Mouse   257 HHINSEHIHGER-KEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLEN 320

  Fly   519 LKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKPYACQLPGCTKRYTDPSSLRKH 582
            ||.|.||||||:||.|:.:||.|||||:||||||| |||.:.|||.|:|||||||||||||||||
Mouse   321 LKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKH 385

  Fly   583 VKNHALRNANGQLRRKSAGGASVPPSGPKKAAKTRRH--------------SESALVQRGVGA-- 631
            ||  .:...:..:.::..|...:|.:.|....:.:|.              .|||:.|:..||
Mouse   386 VK--TVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQS 448

  Fly   632 ---------------GVGVAVPSAPGDQRQHRSN----SCSEALLLQQHQQQQQQQQQQQKQHQP 677
                           ..||.:....|...:..|:    .|..|..|...::.:..:..|..|.:|
Mouse   449 SCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQLHQLRP 513

  Fly   678 ENER-----------TTDRSNCGTGVAANNNSMNFNELSNCIVIIEHNQSGGPAGPAT-----LA 726
            ...|           .......|..|:.:..|.:.:.:|:...:...:....|..|.|     .:
Mouse   514 IGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGAS 578

  Fly   727 TATATTTA-----TATYGNGNMAPAPETEVLSVCSGGGSS----NSNSNNNRYNANINQLSELEQ 782
            :....|.|     .|.|.:...:..|.|...|:...||.|    .|.:....||.|..
Mouse   579 SLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAG------- 636

  Fly   783 LLTTAKPTGTPAASANGISLAN-NNGRANGDSKCHLSEFVSFEYVTKYLTDVYEPQCKSPQPPA 845
               ..:....||.:|:..:.|. ...::.|......|......:...:.|.||     |||||:
Mouse   637 ---VTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHPTSVY-----SPQPPS 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	15/25 (60%)
		C2H2 Zn finger	504..526	CDD:275368	14/21 (67%)
		C2H2 Zn finger	534..556	CDD:275368	16/22 (73%)
		C2H2 Zn finger	564..586	CDD:275368	20/21 (95%)
Gli1	NP_034426.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..78
		Interaction with SUFU. /evidence=ECO:0000250\|UniProtKB:P08151	123..127
		COG5236	<196..>438	CDD:227561	109/247 (44%)
		FOXP-CC	240..>268	CDD:292777	12/27 (44%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P08151	286..294		3/7 (43%)
		zf-H2C2_2	290..317	CDD:290200	15/26 (58%)
		C2H2 Zn finger	306..328	CDD:275368	14/21 (67%)
		zf-H2C2_2	320..347	CDD:290200	18/26 (69%)
		C2H2 Zn finger	336..359	CDD:275368	16/22 (73%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P08151	348..353		3/4 (75%)
		C2H2 Zn finger	367..388	CDD:275368	20/22 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..487		24/110 (22%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P08151	378..384		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..583		7/54 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..649		12/60 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..692		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	832..891
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1064..1093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940