Protein Alignment lmd and Gli1

DIOPT Version :10

• Sequence 1: NP_732811.1
• Gene: lmd / 42717
• FlyBaseID: FBgn0039039
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_001178839.1
• Gene: Gli1 / 140589
• RGDID: 621673
• Length: 1109
• Species: Rattus norvegicus
• Alignment Length: 630
• Identity: 181/630 - (28%)
• Similarity: 258/630 - (40%)
• Gaps: 195/630 - (30%)

  Fly   215 SPCSSP-----HLDAWLNFNLGEISAAASSSAASPKLGNVFEEQVKEE--ASPAKLPSMNSTFGT 272
            |.|:||     ||               |....||.||  |..|:..:  .||        .:|.
  Rat   112 SRCTSPGGSYGHL---------------SIGTMSPSLG--FPPQMSHQKGTSP--------PYGV 151

  Fly   273 PKCIPMCASNYEDYANLYQQGSGYSTENYHNNMAQVVEKPNREHKAIWTI-DELDELMLGEQQQF 336
            ..|:|..::          |||            .::...:|..:|...: .||| :|:|:..:
  Rat   152 QPCVPHDST----------QGS------------MMLHPQSRGPRATCQLKSELD-IMVGKCPE- 192

  Fly   337 LQHHLQQQHLQEQQEQLHQPHGQEQQTQNCKDDLVNYLSDEFIKAEEFRSLDSDDDENYNEEEDD 401
                      :..:..:..|:....|     |.|:..|               |..|:...||
  Rat   193 ----------EPLEGDMSSPNSTSTQ-----DHLLGML---------------DGREDLEREE-- 225

  Fly   402 LDNDVFAPPAESDPKPDSTCCDPEAEPENEVIPLICRWTGCDEEFPHQQAFVEHIEKCHVDVRKG 466
                          ||     :||:..|.:     |||.||.:||..|:..|.||...|:...:
  Rat   226 --------------KP-----EPESVYETD-----CRWDGCSQEFDSQEQLVHHINSEHIHGER- 265

  Fly   467 EDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERP 531
            ::|.|.|..|.|..:||.|:|.|::|||.|:||||:||.|.||.|::|||||||.|.||||||:|
  Rat   266 KEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKP 330

  Fly   532 YGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKPYACQLPGCTKRYTDPSSLRKHVKNHALRNANGQL 595
            |.|:.:||.|||||:||||||| |||.:.|||.|:|||||||||||||||||||  .:...:..:
  Rat   331 YMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVK--TVHGPDAHV 393

  Fly   596 RRKSAGGASVPPSGPKKAAKTRRHSESALVQRGVGAG---------VGVAVPSAPGDQRQHRSNS 651
            .::..|...:|.:.|....:.:|..|.       |:|         .|.....:||.|     :|
  Rat   394 TKRHRGDGPLPRAQPLSTVEPKREREG-------GSGREESRLTVPEGTMPQQSPGAQ-----SS 446

  Fly   652 CSEALLLQQHQQQQQQQQQQQKQHQPENERTTDRSNCGTGV-AANNNSMNFNELSNCIVIIEHNQ 715
            ||                   ..|.|..    ..:|..:|| .|.|...:..:||:.
  Rat   447 CS-------------------SDHSPAG----SAANTDSGVEMAGNAGGSTEDLSSL-------- 480

  Fly   716 SGGPAGPATLATATATTTATAT-----------YGNGNM-------APAPETEVLS--VCSGGGS 760
               ..||...||..:|......           .|:..:       |.||.:..|.  |.....|
  Rat   481 ---DEGPCVAATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRS 542

  Fly   761 SNSNSNNNRYNANINQLSELEQLLTTAKPTGTPAASANGISLANN 805
            |:|:|.::.|  .:::.|.|........|....|:|..|::.|.:
  Rat   543 SSSSSISSAY--TVSRRSSLASPFPPGSPPENGASSLPGLTPAQH 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	SFP1	<493..585	CDD:227516	69/92 (75%)
		C2H2 Zn finger	504..526	CDD:275368	14/21 (67%)
		C2H2 Zn finger	534..556	CDD:275368	16/22 (73%)
		C2H2 Zn finger	564..586	CDD:275368	20/21 (95%)
Gli1	NP_001178839.1	COG5236	<196..>433	CDD:227561	114/292 (39%)
		FOXP-CC	237..>265	CDD:465036	12/27 (44%)
		C2H2 Zn finger	303..325	CDD:275368	14/21 (67%)
		C2H2 Zn finger	333..356	CDD:275368	16/22 (73%)
		C2H2 Zn finger	364..385	CDD:275368	20/22 (91%)
		PHA03247	<561..867	CDD:223021	5/25 (20%)