DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lmd and glis3

DIOPT Version :9

Sequence 1:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_002934220.1	Gene:	glis3 / 100496527	XenbaseID:	XB-GENE-984727	Length:	922	Species:	Xenopus tropicalis

Alignment Length:	947	Identity:	264/947 - (27%)
Similarity:	360/947 - (38%)	Gaps:	294/947 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SSISGKEAASCYG-------------GFMSPPLSANITANNG---------EREMFRVPGA---K 63
            |.||||  .||..             |.:|||.:...||.|.         ..:...:|.:   .
Frog   131 SKISGK--GSCNNLMVTSSPMMVQRLGPISPPANQAATACNQIGPSLQRTFNLQHLAIPSSDTRS 193

  Fly    64 VETNESYACGELQFPDFSHLCFAAETPNSVFSDCHNY----AGQDQQQDSDQDDIVCAAAENTGM 124
            :.:.||.|...|...: ||...:.:...|     |.|    :....|..||..||:...   .|.
Frog   194 LMSRESLASTTLSLTE-SHSTMSVKQEWS-----HGYRILPSNHGSQNSSDPGDILSIP---PGT 249

  Fly   125 PYQQGQYTQLNREDIFRFEPEDIARLTGESELPGMLQHPQTPYTPYTPYTPYTPCSAQNSQYA-- 187
            .......|......:|.||..                  .:|| |...::.....||::.:.|
Frog   250 SMSNNSVTNSLPSYLFGFESN------------------SSPY-PSPRHSSTRSHSARSKKRALS 295

  Fly   188 VQPANDSINLDIDYFNYDEINCQSKNQSPCSSPHLDAWLNFNLGEISAAASSSAASPKLGNVFEE 252
            :.|.:|.|.:|   ||      .....||.|   |.|::|
Frog   296 LSPLSDGIGID---FN------TIIRTSPTS---LVAYIN------------------------- 323

  Fly   253 QVKEEASPAKLPSMNSTFG-----TPKCI-PMCASNYEDYANLYQQGSGYSTENYHNNMAQVVEK 311
              ...||||.:......:|     ...|| |.||.:
Frog   324 --GSRASPATISPQPEVYGHFLGVRGSCIPPSCAGS----------------------------- 357

  Fly   312 PNREHKAIWTID--ELDELMLGEQQQFLQHHLQQQHLQEQQEQLHQPHGQEQQTQNCKDDLVNYL 374
             |.:...:.|.|  .|.|.:..|.|:..|  |:|.:||                   .|.:.|.:
Frog   358 -NSQRSLLATTDNISLPENVTAEYQRMQQ--LEQNNLQ-------------------SDPMNNMV 400

  Fly   375 SDEFIKAEEFRSLDSDDDENYNEEEDDLDND----VFAPPAESDPKPDSTCCDPE---------- 425
            ..:.:...:.:|:.:...|...:....:...    :.|||....|.|      |.
Frog   401 VRQGVGVADSQSIGALKSERVEDFSGGMATQTPLPLPAPPPHQGPPP------PYHVHQHMHQHD 459

  Fly   426 --------AEPENEVIPLI--------------CRWTGCDEEFPHQQAFVEHIEKCHVDVRKGED 468
                    :.|..:.:||:              |||..|...:..|:..|.||||.|:|.|||||
Frog   460 LLNHSHRLSLPPTDTVPLLEEEGEIDDFNGKHCCRWIDCSSMYEQQEELVRHIEKVHIDQRKGED 524

  Fly   469 FSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYG 533
            |:|||..|||||||||||||||||||||||||||||.|.||.||||||||||||.||||||:||.
Frog   525 FACFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYL 589

  Fly   534 CQYKGCLKAFSNSSDRAKHQRTHYDTKPYACQLPGCTKRYTDPSSLRKHVKNHALRN--ANGQLR 596
            ||:.||.||||||||||||||||.||||||||:|||:||||||||||||||.|:.::  |..:||
Frog   590 CQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSSKDQQARKKLR 654

  Fly   597 RKS-------AGGASVPPSGPKKAAKTRRHSESAL---------VQRGV----------GAGVGV 635
            .::       :...::.|..|  |...:..|||::         |..|.          |...|.
Frog   655 SRTDLDQEILSDCLTIQPLQP--ATSPQDPSESSMGRSPGPVHDVYPGAMFSSTHSSRSGTAGGT 717

  Fly   636 AVPSAPGDQRQHRSNSCSEALLLQQHQQQQQQQQQQQKQHQPENERTTDRSNCGTGVAANNNSMN 700
            ..|..|.......||       :|......|.|.......:|.::|.       .|.|.:.:.::
Frog   718 VPPPLPPSHPSPASN-------IQGSPHNPQSQLPPLTPMEPGSDRF-------RGAAPSPHHLS 768

  Fly   701 FNELSNCIVIIEHNQSGGPAG--------PATLATATAT-TTATATYGNGNMAPAPETEVLSVCS 756
            ...|:            ||.|        ||.:.....| ..|..|..|    |:.::..|.|..
Frog   769 PQRLT------------GPPGMMQRRTPQPAQVQQTGGTYLKAYPTITN----PSVQSSNLHVQG 817

  Fly   757 GGGS--------SNSNSNNNRYNANINQLSELEQLLTTAKPTGT-------PAASANGISLANNN 806
            ..|.        .|.:..|.::.:..|.....|..|:.|....|       ...|.:||::.:..
Frog   818 FYGQLQTFCPPHYNDSQRNMQHGSACNMGPPFEDCLSHACGNKTEFDGFHRAFTSHSGITVYDFP 882

  Fly   807 GRAN---GDSKCHLSEFVSFEYVT------KYLTDVY 834
            |.:.   |:|:.:.||..||..:.      ..|:.||
Frog   883 GGSAGLFGESQRNGSEDTSFLQINAIDRCPSQLSSVY 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	22/25 (88%)
		C2H2 Zn finger	504..526	CDD:275368	17/21 (81%)
		C2H2 Zn finger	534..556	CDD:275368	18/21 (86%)
		C2H2 Zn finger	564..586	CDD:275368	19/21 (90%)
glis3	XP_002934220.1	C2H2 Zn finger	497..516	CDD:275368	7/18 (39%)
		C2H2 Zn finger	527..552	CDD:275368	22/24 (92%)
		SFP1	<549..643	CDD:227516	80/93 (86%)
		C2H2 Zn finger	560..582	CDD:275368	17/21 (81%)
		C2H2 Zn finger	590..612	CDD:275368	18/21 (86%)
		C2H2 Zn finger	620..642	CDD:275368	19/21 (90%)
		Atrophin-1	632..>855	CDD:367360	53/254 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9717
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48090
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	1	1.000	-	-		X3347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030