DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6688 and PDZD7

DIOPT Version :9

Sequence 1:	NP_651110.1	Gene:	CG6688 / 42716	FlyBaseID:	FBgn0039038	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001182192.1	Gene:	PDZD7 / 79955	HGNCID:	26257	Length:	1033	Species:	Homo sapiens

Alignment Length:	458	Identity:	98/458 - (21%)
Similarity:	147/458 - (32%)	Gaps:	171/458 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSNEDGQHGDGSSVRLLRIPRAAPAMENY--GFQLTRSK-WDPYPWVCEVAAGTPAALCGLKPGD 72
            ||:|||       ||  ||.......:::  ||.:...| :....:|.:|..|..|...|:|.||
Human   201 TSSEDG-------VR--RIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGD 256

  Fly    73 CVLEVNGNDVLGLRVSEIAKMVKSQ----------------KDCVTILCWNSECDKDCDTNSICC 121
            .||..||.....:..|:..:::|.|                |:.|:..||     .|..:|.:
Human   257 QVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEMVSEYCW-----LDRLSNGV-- 314

  Fly   122 APMPTSLRRLSLVLESILRLVECPVCGVTISPPAMQCQNGHLLCVDCRIRSERCPVCRDFYTPRR 186
                  |::||...||...:..|     ..|.|   ..:|.|       .|:|..:|.....|
Human   315 ------LQQLSPASESSSSVSSC-----ASSAP---YSSGSL-------PSDRMDICLGQEEP-- 356

  Fly   187 ALLAEQIFLTIANAFEMCRSENKLRQKLFAGITRPVVGRQD-----------RITGQDTWRKRRP 240
                                          |...|..||.|           |:   :||...||
Human   357 ------------------------------GSRGPGWGRADTAMQTEPDAGGRV---ETWCSVRP 388

  Fly   241 VLPTNKFLTKLLEGCAYSTDN----------LSPSNAATLL----RTNTTDVAGDS-----SEIP 286
                    |.:|...|..:|.          ||.|....||    |.........|     .|..
Human   389 --------TVILRDTAIRSDGPHPGRRLDSALSESPKTALLLALSRPRPPITRSQSYLTLWEEKQ 445

  Fly   287 ARTSPVTATPPE-------RTTMHA-------------------TLDANAAHPSLSTNDLQQE-G 324
            .|....:.:|.|       :|.|:.                   |||:.:...:....|:::. |
Human   446 QRKKEKSGSPGEKGALQRSKTLMNLFFKGGRQGRLARDGRREAWTLDSGSLAKTYPRLDIEKAGG 510

  Fly   325 VKPNAEGV------DEESGTNSSHISATSLHGPPLPASVSPGINESSGLQPVRIPPVTPSQDLPQ 383
            |.|..:.|      |:|.|  .:.:||.|    ..|:|..|.::|.......|.|.:   |||.|
Human   511 VGPVQKFVTWRLRRDQERG--RALLSARS----GSPSSQLPNVDEQVQAWESRRPLI---QDLAQ 566

  Fly   384 QVV 386
            :::
Human   567 RLL 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6688	NP_651110.1	PDZ_signaling	24..104	CDD:238492	24/98 (24%)
PDZD7	NP_001182192.1	PDZ_signaling	84..164	CDD:238492
		PDZ_signaling	209..289	CDD:238492	20/79 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..380		16/103 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..464		3/19 (16%)
		HN_PDZD7_like	554..630	CDD:259824	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..864
		PDZ_signaling	860..948	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900