DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6688 and dlg5a

DIOPT Version :9

Sequence 1:	NP_651110.1	Gene:	CG6688 / 42716	FlyBaseID:	FBgn0039038	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_005156738.1	Gene:	dlg5a / 569065	ZFINID:	ZDB-GENE-030131-3149	Length:	1961	Species:	Danio rerio

Alignment Length:	409	Identity:	91/409 - (22%)
Similarity:	132/409 - (32%)	Gaps:	156/409 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RKSAGGFHSTSNEDGQHGDGSSVRLLRIPRAAPAMENYGFQLTRSKWDPYPWVCEVAAGTPAALC 66
            |||.||...||         ..:.|:....|..|:|...|            |..:|.|:|||..
Zfish   785 RKSLGGRLVTS---------VHINLIGHKDAGIALEGGVF------------VAGIAPGSPAARE 828

  Fly    67 G-LKPGDCVLEVNGNDVLGLRVSEIAKMVKSQKDCVTILCWNSECDKDCDTNSICCAPMPTSLRR 130
            | |..||.::.:||          ||...||..:|..:|...                      |
Zfish   829 GSLTIGDRLIAING----------IALDNKSLSECEALLRGG----------------------R 861

  Fly   131 LSLVLESILRLVECPVCGVTISPPAMQCQ--NGHLLCVDCRIRSER-----CPVCRDFYT----- 183
            .||.| |:::.......|..|.....:.:  ||.:...|...|:.|     .....|.|:
Zfish   862 DSLAL-SLMKFFPQSTSGQNIFESLREAEKSNGRIHLTDVHSRNSRNLKHNSSTQTDIYSCDTAG 925

  Fly   184 PRR--------ALLAEQIFLTI--------------------ANAF-EMC--RSENKLRQKLFAG 217
            .||        :|.:|:....|                    |:|| |:|  |||:
Zfish   926 ERRKTRSDAEESLFSERKVFPISTLHPNTLRPASELGPVRYSASAFQEVCYTRSES--------- 981

  Fly   218 ITRPVVGRQDRITGQDTWRKRRPVLPTNKFLTKLLEGCAYSTDN-------LSPS------NAAT 269
                 || .:.:|.:.|..|:.    :.....|::.|.|.:||:       .||.      :|.|
Zfish   982 -----VG-PECVTLETTLEKKH----SGGTWPKMVVGVAMTTDSPAQLSIYRSPKQRKSIFDADT 1036

  Fly   270 LLRTNTTDVAGDSSEIP--ARTSPVTATPPERTTMHATLDANAAHPSLSTNDLQQEGVKPNAEGV 332
            ..|.:|...|......|  |.::|...|||.|:....                    .|...:|
Zfish  1037 FKRPDTPSKADYHGPQPLKADSAPTPPTPPTRSDSFK--------------------FKHKHQG- 1080

  Fly   333 DEESGTNSSHISATSLHGP 351
               |.|:.|.|||.|:..|
Zfish  1081 ---SSTSESTISAMSISEP 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6688	NP_651110.1	PDZ_signaling	24..104	CDD:238492	22/80 (28%)
dlg5a	XP_005156738.1	CARD	9..88	CDD:260018
		Takusan	128..211	CDD:282652
		Taxilin	295..627	CDD:286771
		RILP-like	338..460	CDD:304877
		SH3BP5	444..648	CDD:283045
		PDZ_signaling	696..783	CDD:238492
		PDZ_signaling	793..866	CDD:238492	28/125 (22%)
		PDZ	1381..1463	CDD:214570
		dbPDZ_assoc	1461..1541	CDD:293216
		PDZ	1541..1623	CDD:214570
		SH3_DLG5	1639..1701	CDD:212794
		Guanylate_kin	1780..1949	CDD:279019
		NK	1794..1950	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900