DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6688 and lnx2b

DIOPT Version :9

Sequence 1:	NP_651110.1	Gene:	CG6688 / 42716	FlyBaseID:	FBgn0039038	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	396	Identity:	78/396 - (19%)
Similarity:	133/396 - (33%)	Gaps:	118/396 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSNEDGQHGDGSSVRLLRIPRAAPAMENYGFQLTRSKWDPYPWVCEVAAGTPAALCG-LKPGDCV 74
            ::|::  ||....|.|::..|:    |..|.:|.|...:|..::.::..|..||..| |:..|.|
Zfish   317 STNQN--HGTVIQVTLVKHERS----EALGIKLIRKSEEPGVFILDLLPGGLAAKDGKLRNNDKV 375

  Fly    75 LEVNGNDVLGLRVSEIAKMVKSQKDCVTILCWN----SECDKDCDTNSICCAPMPTSLRRLSLVL 135
            |.:||.|:........|:::::.:..|..:...    ||...:..:......|.|...||.|..:
Zfish   376 LGINGQDLRHGTPESAAQIIQASEMRVNFVVMRLQDVSEEGGEGQSRGARRVPEPQYFRRHSEYM 440

  Fly   136 ESILRLVECPVCGVTISPPAMQCQNGHLLCVDCRIRSERCPVCRDFYTPRRALLAEQIFLTIANA 200
            :               .||      |.....:..:..::        .||::|     .:|||..
Zfish   441 K---------------EPP------GGFSSQEKTVTLKK--------EPRQSL-----GITIAGG 471

  Fly   201 FEMCRSENKLRQKLFAGITRPV--VGRQDRITGQDTWRKRRPVLPTNKFLTKLLEGCAYSTDNLS 263
            .: |||    |..::....:||  :.|...:...|.                ||........:|:
Zfish   472 RD-CRS----RLPVYITSVQPVGCLHRDGTVKTGDV----------------LLSINGIDLTHLT 515

  Fly   264 PSNAATLLRTNTTDVAGDSSEIPARTSPVTATPPERTTMHATLDANAAHPSLSTNDLQQEGVKPN 328
            .:.|.|:|:|.|.     .|.:..|.....|                       :|.:|:|...:
Zfish   516 YNEAVTVLKTQTA-----QSTVTLRVIQTFA-----------------------DDEEQDGESGS 552

  Fly   329 AEGVDEESGTNSSHISATSL--HGPPLPA--------------------SVSPGINESSGLQPVR 371
            .|.:|...|.....|:...|  ....||:                    |:..|..||.|.||..
Zfish   553 REDMDTMEGPKDDDINWVPLWTRWLGLPSCIHWCRDIMLMKTNSESWGFSIVGGYEESRGQQPFF 617

  Fly   372 IPPVTP 377
            |..:.|
Zfish   618 IKTIVP 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6688	NP_651110.1	PDZ_signaling	24..104	CDD:238492	21/80 (26%)
lnx2b	NP_998105.2	RING	46..82	CDD:214546
		PDZ_signaling	210..291	CDD:238492
		PDZ_signaling	325..406	CDD:238492	21/84 (25%)
		PDZ_signaling	451..537	CDD:238492	24/124 (19%)
		PDZ_signaling	587..671	CDD:238492	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900