Protein Alignment CG6688 and PARD3

DIOPT Version :9

• Sequence 1: NP_651110.1
• Gene: CG6688 / 42716
• FlyBaseID: FBgn0039038
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_062565.2
• Gene: PARD3 / 56288
• HGNCID: 16051
• Length: 1356
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 83/440 - (18%)
• Similarity: 140/440 - (31%)
• Gaps: 162/440 - (36%)

  Fly    68 LKPGDCVLEVNGNDVLGLRVSEIAKMVKSQK--DCVTILCWNSE------------------CDK 112
            ||.||.::||||.|::|....|:..:::|.|  ..|::|.:..|                  .:.
Human   505 LKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKET 569

  Fly   113 DCDTNSICCAPMPTSLRRLSLVLESILRLVECPVCGVTISPPAMQCQ--------------NGHL 163
            ..:...|...|..|   |..|..|  :.|.:....|:.:|....:.:              ||..
Human   570 KAEDEDIVLTPDGT---REFLTFE--VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGA 629

  Fly   164 LCVDCRIRSERCPVCRD------------FYTPRRALLAE-----QIFLTIANAFEMCRS----- 206
            ...|.|:|.....:..:            ..|.||::..|     .|.|.:|.....|..
Human   630 ASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPG 694

  Fly   207 ----------------ENKLRQKLFAGI------------------------TRPVVG--RQDRI 229
                            |.::...|::||                        ..|.|.  :.|.:
Human   695 SPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTV 759

  Fly   230 TGQDTWRKRRPVLPTNKFLTKLLEGCAYSTDNLSPSNAATLLRTNTTDVAGDSSEIPARTSPVTA 294
            ..:|   .|.||||.:  |:......::.......::|.|..:...:|.| |.|..| ...||.|
Human   760 IIED---DRLPVLPPH--LSDQSSSSSHDDVGFVTADAGTWAKAAISDSA-DCSLSP-DVDPVLA 817

  Fly   295 TPPE------------------------RTTMHATLDANAA-HPSLSTNDLQQEGVKPNAEGVDE 334
            ...|                        :|....::|...| ...|:|.|             |:
Human   818 FQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVD-------------DQ 869

  Fly   335 ESGTNSSHISATSLHGPPLPASVSPGINESSGLQPVR--IPPVTPSQDLP 382
            ::|:.|..:      ||.|      |:.:||.|:.::  :..||.:.|:|
Human   870 KAGSPSRDV------GPSL------GLKKSSSLESLQTAVAEVTLNGDIP 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6688	NP_651110.1	PDZ_signaling	24..104	CDD:238492	14/37 (38%)
PARD3	NP_062565.2	DUF3534	1..146	CDD:288873
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..100
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..262
		PDZ_signaling	272..347	CDD:238492
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..448
		PDZ_signaling	465..544	CDD:238492	14/38 (37%)
		PDZ_signaling	588..681	CDD:238492	15/94 (16%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000250|UniProtKB:Q9Z340	712..936		44/228 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..886		9/45 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	932..1025
		Interaction with FRMD4A. /evidence=ECO:0000250|UniProtKB:Q99NH2	935..1356
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1129..1356

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900