DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6688 and CYHR1

DIOPT Version :9

Sequence 1:	NP_651110.1	Gene:	CG6688 / 42716	FlyBaseID:	FBgn0039038	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001317547.1	Gene:	CYHR1 / 50626	HGNCID:	17806	Length:	404	Species:	Homo sapiens

Alignment Length:	313	Identity:	63/313 - (20%)
Similarity:	106/313 - (33%)	Gaps:	106/313 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 LESILRLVECPVCGVTISPP---AMQCQNGHLLCVDC--------RIRSER--CPVCRDFYTPR- 185
            ||..|..|.|  |.|.:..|   ..||.||||:|..|        |::.|:  ||.||...:..
Human   101 LEERLYSVLC--CTVCLDLPKASVYQCTNGHLMCAGCFIHLLADARLKEEQATCPNCRCEISKSL 163

  Fly   186 --RALLAEQIFLTIANAFEMCRSENKLRQKLFAGITRPVVGR------QDRITGQDTWRKRRPVL 242
              |.|..|:....:.:....|     |||     ..|.::.|      |||:| |..:::
Human   164 CCRNLAVEKAVSELPSECGFC-----LRQ-----FPRSLLERHQKEECQDRVT-QCKYKR----- 212

  Fly   243 PTNKFLTKLLEGCAYSTDNLSPSNAATLLRTNTTDVAGDSSEIPARTSPVTATPPERTTMHATLD 307
                      .||.:.                                    .|....|:|   :
Human   213 ----------IGCPWH------------------------------------GPFHELTVH---E 228

  Fly   308 ANAAHPSLSTNDLQQEGVKPNAEGVDEESGTNSSHISATSLHGPPLPASVSPGIN-ESSGLQPVR 371
            |..|||:.:.::|.:     ..:|:|:      ||.....|:.     |:...:: |..|...|:
Human   229 AACAHPTKTGSELME-----ILDGMDQ------SHRKEMQLYN-----SIFSLLSFEKIGYTEVQ 277

  Fly   372 IPPVTPSQDLPQQVVQTKPASLLYRCPCKLQDPQDPAKDLHQNCCYKSAFRLL 424
            ..|......:.:...:|...::|.:.........|..::.:.:|....:|:||
Human   278 FRPYRTDDFITRLYYETPRFTVLNQTWVLKARVNDSERNPNLSCKRTLSFQLL 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6688	NP_651110.1	PDZ_signaling	24..104	CDD:238492
CYHR1	NP_001317547.1	RING-HC_CYHR1	108..156	CDD:319419	17/49 (35%)
		RING-HC finger (C3HC4-type)	111..155	CDD:319419	15/43 (35%)
		Sina	166..>227	CDD:388509	18/122 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3002
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900