DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6688 and Pard3b

DIOPT Version :9

Sequence 1:	NP_651110.1	Gene:	CG6688 / 42716	FlyBaseID:	FBgn0039038	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001178737.1	Gene:	Pard3b / 301455	RGDID:	1584992	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	410	Identity:	77/410 - (18%)
Similarity:	110/410 - (26%)	Gaps:	165/410 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GFHSTSNEDGQHGDGSSVRLLRIPRAAPAMENYGFQLTRSKWDPYPWVCEVAAGTPAALCGLKPG 71
            ||...:.:...||.|.......:|:.|...:.                            .|:.|
  Rat   394 GFTVVTRDSSIHGPGPIFVKNILPKGAAVKDG----------------------------RLQSG 430

  Fly    72 DCVLEVNGNDVLGLRVSEIAKMVKSQKDCVTILCWNSECDKDCDTNSICCAPMPTSLRRLSLVLE 136
            |.:|||||.||.|....|:..|::|.|...|:                            |||:.
  Rat   431 DRILEVNGRDVTGRTQEELVAMLRSTKQGETV----------------------------SLVIA 467

  Fly   137 SILRLVECPVCGVTISPPAMQCQNGHLLCVDCRIRSERCPVCRDFYTPRRALLAEQIFLTIANAF 201
            .                     |.|..|                   ||........:.....:.
  Rat   468 R---------------------QEGSFL-------------------PRELKGEPDCYALSLESS 492

  Fly   202 EMCRSENKLRQKLFAGITRPVVGRQDRITGQDTWRKRRPVLPTNKFLTKLLEGCAYSTDNLSPSN 266
            |....|..|.....||:...:.|.:.|.||.|          ...|:..::.|.|...|.
  Rat   493 EQLTLEIPLNDSGSAGLGVSLKGNKSRETGTD----------LGIFIKSIIHGGAAFKDG----- 542

  Fly   267 AATLLRTNTTDVAGDSSEIPARTSPVTATPPERTTMHATLDANAAHPSLST--NDLQQEGVKPNA 329
               .||.|...:|.:..                     ||...:.|.::.|  ..:..||   |.
  Rat   543 ---RLRMNDQLIAVNGE---------------------TLLGKSNHEAMETLRRSMSMEG---NI 580

  Fly   330 EGVDEESGTNSSHISATSLHGPPLPASVSPGINESSGLQPVRIPPVTPSQDLPQQVV---QTKPA 391
            .|:          |....|.....|..   .|:|...|.       .|..:..|:.:   :...:
  Rat   581 RGM----------IQLVILRRLERPLE---EISECGALS-------RPCFENCQEALSASRRNDS 625

  Fly   392 SLLYRCPCKLQDPQDPAKDL 411
            ||||  ||....|||..|||
  Rat   626 SLLY--PCGTYSPQDKRKDL 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6688	NP_651110.1	PDZ_signaling	24..104	CDD:238492	18/79 (23%)
Pard3b	NP_001178737.1	DUF3534	1..143	CDD:288873
		PDZ_signaling	201..288	CDD:238492
		PDZ	380..469	CDD:214570	26/151 (17%)
		PDZ_signaling	501..589	CDD:238492	25/139 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900