DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6688 and WHRN

DIOPT Version :9

Sequence 1:	NP_651110.1	Gene:	CG6688 / 42716	FlyBaseID:	FBgn0039038	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_011516787.1	Gene:	WHRN / 25861	HGNCID:	16361	Length:	918	Species:	Homo sapiens

Alignment Length:	474	Identity:	93/474 - (19%)
Similarity:	152/474 - (32%)	Gaps:	148/474 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRKSAGGFHSTSN--EDGQH-------GDGSSVRLLRIPRAAPAMENYGFQLTRSKWDPYPWVCE 56
            :|:..|...||.:  :.|..       |||.|:. |.|...|    .||..:..:..||
Human   258 LRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLG-LTIRGGA----EYGLGIYITGVDP------ 311

  Fly    57 VAAGTPAALCGLKPGDCVLEVNGNDVLGLRVSEIAKMVKSQKDCVTILCWNSECDKDCDTNSICC 121
               |:.|...|||.||.:|||||...|.:...|..:::||.:..:..:       ||       .
Human   312 ---GSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTV-------KD-------V 359

  Fly   122 APMP---TSLRRLSLVLESILRLVECPVCG-----------------------VTISPPAMQC-- 158
            ..:|   |::.....:..|.:|.......|                       ||:|....|.
Human   360 GRLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGNQTRV 424

  Fly   159 ----QNGHLLCVDCRIRSERCPVCRDFYTPRRALLAEQIFLTIANAFEMCRSENK--LRQKLFAG 217
                |..|||       :|:......:|.......:..:...:...|::..:..|  |..::...
Human   425 LLEEQARHLL-------NEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVRGT 482

  Fly   218 ITRPVVGRQDRITGQ---DTWRKRRPVLPTNKFLTKLLEGCAYSTDNLSPSNAAT---------- 269
            |:...:.|.|.:..:   ::.:.|:|..|.        .|..||..:.|.:.::|
Human   483 ISPQDLERFDHLVLRREIESMKARQPPGPG--------AGDTYSMVSYSDTGSSTGSHGTSTTVS 539

  Fly   270 ----------LLRTNTTD-------VAGDSSEIP--------------ARTSPVTATPPERTTMH 303
                      .|..||.|       |.|:.:.:|              :...|:...||    :.
Human   540 SARERLLWLIDLMENTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPP----LA 600

  Fly   304 ATLDANAAHP-SLSTNDLQQEGVKPNAEGVDEESGTNSSHISATSLHGPPLPASVSPGINESSGL 367
            ...|.....| .|...|||.....|:..|         :..||.....||...:.:||.:.:..|
Human   601 QGNDLPLGQPRKLGREDLQPPSSMPSCSG---------TVFSAPQNRSPPAGTAPTPGTSSAQDL 656

  Fly   368 --QPV--RIPPVTPSQDLP 382
              .|:  .:.|..||...|
Human   657 PSSPIYASVSPANPSSKRP 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6688	NP_651110.1	PDZ_signaling	24..104	CDD:238492	23/79 (29%)
WHRN	XP_011516787.1	HN_L-whirlin_R1_like	37..112	CDD:259822
		PDZ_signaling	138..215	CDD:238492
		PDZ_signaling	277..357	CDD:238492	27/100 (27%)
		HN_L-whirlin_R2_like	419..499	CDD:259823	13/86 (15%)
		PDZ_signaling	827..898	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900