DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6688 and Grid2ip

DIOPT Version :9

Sequence 1:	NP_651110.1	Gene:	CG6688 / 42716	FlyBaseID:	FBgn0039038	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001152793.1	Gene:	Grid2ip / 170935	MGIID:	2176213	Length:	1203	Species:	Mus musculus

Alignment Length:	436	Identity:	98/436 - (22%)
Similarity:	145/436 - (33%)	Gaps:	123/436 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 STSNEDGQHGDGSSVRLLRIPRAAPAMENYGFQLTRSKWDPYPWVCEVAAGTPAALCGLKPGDCV 74
            :||...|:.|.|...|.:|:.:.     |..|..|.....|. |:..|..|:||....||.||.:
Mouse   252 ATSLLGGRTGPGGPRRTVRVYKG-----NKSFGFTLRGHGPV-WIESVLPGSPAENASLKSGDRI 310

  Fly    75 LEVNGNDVLGLRVSEIAKMVKSQKDCVTILCWNSECDKDCDTNSI---CCAPMPTSLRRLSLVLE 136
            |.:||.|:......::..|::......|::..........|::|:   ..|...|||:.::.:|.
Mouse   311 LFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGPVPFASDSDSLDSPTRASALTSLQWVADILP 375

  Fly   137 SILRLVECPVCGVTISPPAMQCQNGHLLCVDCRIRSERCPVCRDFYTPRRALLAEQIFLTIANAF 201
            |.:|     |.|.|.|.     |..|||     ...||..|||..   .|......|...|.:.:
Mouse   376 SSIR-----VQGRTFSQ-----QLDHLL-----TPPERYGVCRAL---ERFFQHRNIDTLIVDVY 422

  Fly   202 EMCRSENKLRQKLFAGITRPVVGRQDRITGQDTWRKRRPVLPTNKFLTKLLEGCAYSTDNLSPSN 266
                               ||:   |....|..|          :||.:||   .|....|....
Mouse   423 -------------------PVL---DTPAKQVLW----------QFLYQLL---TYEEQELCQEK 452

  Fly   267 AATLL-RTNTTDVAGDSSEIPARTSPVTATPPERTTMHATLDANAAHPSLSTNDLQQEGVK---- 326
            .|..| .|..|:........|..|...|..|..|:::.|:        |:....|:.:|::
Mouse   453 IACFLGYTAMTEPESSLDLEPESTPEPTPEPQPRSSLRAS--------SMCRRSLRSQGLETSLS 509

  Fly   327 -----------PNAEGVDEESGTNSSHISATSLHGPPLP-------ASVSPGINES-----SGLQ 368
                       |...| :.::|      ..|||...|.|       |.:...:|.|     ..:.
Mouse   510 CGPGDCPEMPLPLIPG-ERQAG------DGTSLPETPNPKMMSAVYAELESRLNSSFKGKIGTMS 567

  Fly   369 PVRIPPVTPSQDLPQQVVQTK----------PASLLYRCPCKLQDP 404
            ..|..|..||      :|.|.          |:..|...||  .||
Mouse   568 KSRASPPVPS------LVGTSGPRTLSGVSWPSDRLLPSPC--YDP 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6688	NP_651110.1	PDZ_signaling	24..104	CDD:238492	21/79 (27%)
Grid2ip	NP_001152793.1	PDZ_signaling	9..69	CDD:238492
		HN_L-delphilin-R1_like	122..201	CDD:259820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..270		6/17 (35%)
		PDZ_signaling	269..342	CDD:238492	20/78 (26%)
		HN_L-delphilin-R2_like	378..457	CDD:259821	29/131 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..541		16/89 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..586		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..656
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..821
		FH2	812..1180	CDD:280362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900