DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34375 and SIAH3

DIOPT Version :10

Sequence 1:NP_001163693.1 Gene:CG34375 / 42715 FlyBaseID:FBgn0085404 Length:568 Species:Drosophila melanogaster
Sequence 2:NP_942146.2 Gene:SIAH3 / 283514 HGNCID:30553 Length:269 Species:Homo sapiens


Alignment Length:169 Identity:43/169 - (25%)
Similarity:59/169 - (34%) Gaps:44/169 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   384 ANKLSTVAMQALAVVENSGGASLSAGSHKQAPAAGVNQELPLEAGSI----------GRREWQLL 438
            |.::.:.|.|.:.||..:  .:|...|.::|    |.|..| |.||.          ..|....|
Human    24 AKRVFSAAGQLVCVVNPT--HNLKYVSSRRA----VTQSAP-EQGSFHPHHLSHHHCHHRHHHHL 81

  Fly   439 RHLSGDHRLAVLQIYGTFGERLHVRPQLPLEGVACLRLSEESS---------TFGHVR-VHTFFL 493
            ||.:..|.|...:      ..||..|..|     ||.:....|         ...|:| :|.   
Human    82 RHHAHPHHLHHQE------AGLHANPVTP-----CLCMCPLFSCQWEGRLEVVVPHLRQIHR--- 132

  Fly   494 AVIAIGGGDEHAVFLWHLDHLPHGPTFETVIETPGHRFL 532
              :.|..|.| .|||....|||....:..:....||.||
Human   133 --VDILQGAE-IVFLATDMHLPAPADWIIMHSCLGHHFL 168

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34375NP_001163693.1 PDZ_canonical 11..81 CDD:467153
RING-HC_SIAHs 128..165 CDD:438233
SIAH3NP_942146.2 Sina 133..259 CDD:239753 13/37 (35%)
Blue background indicates that the domain is not in the aligned region.

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