Protein Alignment Nha2 and NHX1

DIOPT Version :9

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_010744.3
• Gene: NHX1 / 852066
• SGDID: S000002864
• Length: 633
• Species: Saccharomyces cerevisiae
• Alignment Length: 515
• Identity: 96/515 - (18%)
• Similarity: 187/515 - (36%)
• Gaps: 109/515 - (21%)

  Fly   212 PGS---VSGYPTPNATPGDEYKGPKWWLYIRSHWVNTSELVALLAIFLGLWAMGWVLLPEYSQPP 273
            |||   ::|.|..:..|..|.....|.|:|           .||.:...||:..::.........
Yeast    37 PGSDDPIAGDPDVDLNPVTEEMFSSWALFI-----------MLLLLISALWSSYYLTQKRIRAVH 90

  Fly   274 TVIMRIAFLFVGAQISGILVTFV---HLPDML---GMLFFGVLYANLGLANFEGYQKFEL-FLRE 331
            ..::.|   |.| .:.|:::...   ::.|.:   ...||.||...:.|.:  ||:..:: |...
Yeast    91 ETVLSI---FYG-MVIGLIIRMSPGHYIQDTVTFNSSYFFNVLLPPIILNS--GYELNQVNFFNN 149

  Fly   332 MALINIMLLAGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIAGLANLTLSMPWLWGIALGLVITA 396
            |..|.|..:.|             ..:...::..|:.:....||.::.:|  :...:::|..::|
Yeast   150 MLSILIFAIPG-------------TFISAVVIGIILYIWTFLGLESIDIS--FADAMSVGATLSA 199

  Fly   397 VSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMF---------GVIISVIFSTTSL 452
            ..|..::::....|.|     ..::|:|:..:..||.::|.||         ....|.:|....|
Yeast   200 TDPVTILSIFNAYKVD-----PKLYTIIFGESLLNDAISIVMFETCQKFHGQPATFSSVFEGAGL 259

  Fly   453 TQQVLQGPIGIGIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVMGSRVIGYTSAGA 517
            .  ::...:.:.||::.|.|...:|::...|..........:|..........|..:.|..|  .
Yeast   260 F--LMTFSVSLLIGVLIGILVALLLKHTHIRRYPQIESCLILLIAYESYFFSNGCHMSGIVS--L 320

  Fly   518 LGC-VTTAFIARIGWRREETRLTPQQLQAQQIASVPKRLDLMWKFLKPVSFALIGKEINFNVLQG 581
            |.| :|....|.....|.      .|:..:.|..:..||.      :...|..:|.|: |..::
Yeast   321 LFCGITLKHYAYYNMSRR------SQITIKYIFQLLARLS------ENFIFIYLGLEL-FTEVE- 371

  Fly   582 HVIGYGALLVLVGSLFRLAFAYLSTY----------------------GGNLS-RKERAYITISG 623
              :.|..||::|.::......:.:.:                      |.|:| ..|..|    .
Yeast   372 --LVYKPLLIIVAAISICVARWCAVFPLSQFVNWIYRVKTIRSMSGITGENISVPDEIPY----N 430

  Fly   624 FPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIF----TAPLGAILMLR 679
            :...|..|.|.. |:.:|.|..:....:..|...:|::.||.:|.    ||.:..:|.::
Yeast   431 YQMMTFWAGLRG-AVGVALALGIQGEYKFTLLATVLVVVVLTVIIFGGTTAGMLEVLNIK 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	82/445 (18%)
NHX1	NP_010744.3	b_cpa1	55..611	CDD:273294	90/497 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900