Protein Alignment Nha2 and Slc9a8

DIOPT Version :10

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: XP_036018592.1
• Gene: Slc9a8 / 77031
• MGIID: 1924281
• Length: 604
• Species: Mus musculus
• Alignment Length: 480
• Identity: 94/480 - (19%)
• Similarity: 164/480 - (34%)
• Gaps: 160/480 - (33%)

  Fly   282 LFVGAQISGILVTFVH---------LPDMLGMLFFGVLYANL-------GLANFEGYQKFE---L 327
            :|....:..|.:..||         ||:.:.::..|:|...:       .|||::..:.|.   .
Mouse    57 IFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKVIEFKKLANWKEEEMFRPNMF 121

  Fly   328 FLREMALINIMLLAGLGL-DGDAFKRLWFMILRLTLLPTIVEVAAIA------GLANLTLSMPWL 385
            ||  :.|..|:..:|..| .|:.|:.:..:.| ..:..|.:....:.      |.|::...:...
Mouse   122 FL--LLLPPIIFESGYSLHKGNFFQNIGSITL-FAVFGTAISAFVVGGGIYFLGQADVISKLNMT 183

  Fly   386 WGIALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFM------------ 438
            ...|.|.:|:||.|...:.:...|..|.:     ::.|::..:..||.|:|.:
Mouse   184 DSFAFGSLISAVDPVATIAIFNALHVDPV-----LNMLVFGESILNDAVSIVLTNTAEGLTRKHM 243

  Fly   439 ------------FGVIISVIFSTTSLTQQVLQGPIG----------------IGIGLVFGYL-YG 474
                        .|..:.:.|.:.:|  ..|.|.|.                .|:.::|.|| ||
Mouse   244 SDVSGWQTFSQALGYFLKMFFGSAAL--GTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYG 306

  Fly   475 SMLQYLPSRNATYANGLRFVLTILGGTIAVMGSRVI--GYTSAGALGCVTTAFIARIGWRREETR 537
                        .|.|:.     |.|.:|::.|.::  .||                     ...
Mouse   307 ------------LAEGIS-----LSGIMAILFSGIVMSHYT---------------------HHN 333

  Fly   538 LTP--QQLQAQQIASVPKRLDLMWKFL-KPVSFALIGK---------EINFNVLQGHVIGYGALL 590
            |:|  |.|..|.:.:|        .|| :...||.:|.         ||:|.:       :..:|
Mouse   334 LSPVTQILMQQTLRTV--------AFLCETCVFAFLGLSIFSFPHKFEISFVI-------WCIVL 383

  Fly   591 VLVG---SLFRLAFAYLSTYGGNLSRKERAYITISGFPKATVQAALGPVALDMARAASVASPEQL 652
            ||.|   ::|.|::.........::.|....:..||...|.      |.||.:  ...:...|:.
Mouse   384 VLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAI------PYALSL--HLGLEPMEKR 440

  Fly   653 ALAGNLLIISVLAIIF-----TAPL 672
            .|.|...|:.||..|.     |.||
Mouse   441 QLIGTTTIVIVLFTILLLGGSTMPL 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	NhaP	279..>686	CDD:439796	94/480 (20%)
Slc9a8	XP_036018592.1	Na_H_Exchanger	59..>483	CDD:470090	93/478 (19%)