Protein Alignment Nha2 and Slc9b1

DIOPT Version :9

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_083222.2
• Gene: Slc9b1 / 74446
• MGIID: 1921696
• Length: 565
• Species: Mus musculus
• Alignment Length: 682
• Identity: 180/682 - (26%)
• Similarity: 281/682 - (41%)
• Gaps: 155/682 - (22%)

  Fly    25 SNPFEDSYQMSSCQQDFERDRDANLTPLHMLRRASETVTASILEPEKEHLLGDKPQVPPRAHGST 89
            ||..:|.:| ||...:..:|.|:    .|     .|||     ||:.| |...:|:.|
Mouse     8 SNKKDDGFQ-SSVTVEMSKDPDS----FH-----EETV-----EPKPE-LKEPEPKEP------- 49

  Fly    90 APSAIEAKR-SRQQPNQWQLQQQQQPSSNNNNTKRALAPGDNMTQGAAPQDSQGDILPTRPLHTK 153
            .|...|.|. .|::|      ::::|.......|   .||...||
Mouse    50 EPKEPERKEPERKEP------ERKEPERKEPERK---VPGRRETQ-------------------- 85

  Fly   154 LDIQKIPEDEAGADATQNAATIILTPTSLNLTNTTTQNVAANNAGNSSTTTSTNTNYGPGSVSGY 218
                                               |:...........|.....||       .|
Mouse    86 -----------------------------------TKETQTTEIERKETKKKRGTN-------SY 108

  Fly   219 PTPNATPGDEYKGPKWWLYIRSHWVNTSELVALLAIFLGLWAMGWVLLPEYSQPPTVIMRIAFLF 283
            ..|..|                    .::.:...|..:.||.:.|.|:.:...|...:..:..:|
Mouse   109 CPPQGT--------------------INKTITDGAALIALWTLLWALIGQEVLPGGNLFGLVVIF 153

  Fly   284 VGAQISGILVTFVH------LPDMLGMLFFGVLYANLGLANFEGYQ------KFELFLREMALIN 336
            ..|.:.|.::.|:.      ||.::|||..|....|:.:.    |:      .:...||..||..
Mouse   154 YSAFLGGKILEFIRIPVVPPLPPLIGMLLAGFTIRNVPII----YEFVHIPTTWSSALRNTALTI 214

  Fly   337 IMLLAGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIAGLANLTLSMPWLWGIALGLVITAVSPNV 401
            |::.||||||..|.|.|..:.|||:..|..:|..:.|..::..::.||.||..||.|:.||||.|
Mouse   215 ILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEACSAALFSHFIMNFPWQWGFLLGFVLGAVSPAV 279

  Fly   402 VVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGVIISVIFSTTSLTQQVLQGPIGIGIG 466
            ||..||.|:|:..|:..||.||:.|.::.:|:|||..|...:|::||:.|:...:|.....:.||
Mouse   280 VVPNMLMLQENGYGVEKGIPTLLVAASSMDDIVAITGFNTFLSIVFSSGSVISNILSSLRDVLIG 344

  Fly   467 LVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVMGSRVIGYTSAGALGCVTTAFIARIGW 531
            ::.|.:.|..:||.||.:.......|..|.:.....||:|.:.||...:|.|..:..:|:|...|
Mouse   345 VLVGIVMGVFVQYFPSGDQERLTQRRAFLVLSMCISAVLGCQHIGLHGSGGLVTLVLSFMAAKRW 409

  Fly   532 RREETRLTPQQLQAQQIASVPKRLDLMWKFLKPVSFALIGKEINFNVLQGHVIGYGALLVLVGSL 596
            ..|:..:  |::.|.           .|...:|:.|.|:|.|::...|:...|  |..|..:|
Mouse   410 AEEKVGI--QKIVAN-----------TWNVFQPLLFGLVGTEVSVESLESKTI--GMCLATLG-- 457

  Fly   597 FRLAFAYLSTY----GGNLSRKERAYITISGFPKATVQAALGPVALDMARAASVASPEQLALAGN 657
            ..|:...|||:    ..|...||:.:|.:|..|||||||.|||:||:.||   |.:|.....|..
Mouse   458 LALSVRILSTFVLMSFANFRFKEKVFIALSWIPKATVQAVLGPLALETAR---VMAPHLEGYAKA 519

  Fly   658 LLIISVLAIIFTAPLGAILMLRLAPYWLKHGD 689
            ::.::.|||:.|||.||:|:..|.|..|:..:
Mouse   520 VMTVAFLAILITAPNGALLIGILGPKILEQSE 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	137/422 (32%)
Slc9b1	NP_083222.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..112		34/197 (17%)
		Na_H_Exchanger	207..551	CDD:382399	126/363 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837106
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5939
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103025
Panther	1	1.100	-	-	O	PTHR31102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4408
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.680