DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nha2 and Slc9b2

DIOPT Version :9

Sequence 1:	NP_001247251.1	Gene:	Nha2 / 42710	FlyBaseID:	FBgn0263390	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001102855.1	Gene:	Slc9b2 / 679958	RGDID:	1598112	Length:	547	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	157/505 - (31%)
Similarity:	242/505 - (47%)	Gaps:	38/505 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 GNSSTTTSTNTNYGPGSVSGYPTPNATPGDEYKGPKWWLYIRSHW-----VNTSELVALLAIFLG 257
            ||..|..|.....|...    |..:.......:.|:.:|....|.     :....:|.|
  Rat    42 GNEPTEDSNLLTGGEKK----PQDSLAEPRSLQSPRRFLACPPHGRLAGVITNGTMVVL------ 96

  Fly   258 LWAMGWVLLPEYSQPPTVIMRIAFLF----VGAQISGIL--VTFVHLPDMLGMLFFGVLYANLGL 316
            |||:.|.:......|...:..|..||    .|.::.|::  .|...||.:||||..|.|..|:.:
  Rat    97 LWAVVWSITGPECLPGGNLFGIIILFYCSITGGKLFGLIKFPTLPPLPPLLGMLLAGFLLRNVPV 161

  Fly   317 A--NFEGYQKFELFLREMALINIMLLAGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIAGLANLT 379
            .  |.....|:...||.:||..|::.||||||..|.|:|..:.:||.:.|.|||..|.|.|::..
  Rat   162 ISDNVRIQHKWSSSLRSIALSVILVRAGLGLDSKALKKLKGVCVRLAMGPCIVEACASALLSHFL 226

  Fly   380 LSMPWLWGIALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGVIIS 444
            :.:||.||..||.|:.||||.|||..||.|:|...|:..||.||:.|..:.:|::||..|...:.
  Rat   227 MGLPWQWGFILGFVVGAVSPAVVVPSMLLLQEGGYGVEKGIPTLLMAAGSFDDILAITGFNTCLG 291

  Fly   445 VIFSTTSLTQQVLQGPIGIGIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVMGSRV 509
            |.|||.|....:.:|.:.:.||:..|.|.|..:||.|||:.......|..|.:....:||..|.:
  Rat   292 VAFSTGSTVFNIFRGILEVVIGVATGSLLGFFIQYFPSRDQDNLVWKRAFLVLGFAVLAVFSSVI 356

  Fly   510 IGYTSAGALGCVTTAFIARIGWRREETRLTPQQLQAQQIASVPKRLDLMWKFLKPVSFALIGKEI 574
            ..:..:|.|..:..||:|.:.|..::             :.|.|.:.|.|...:|:.|.|||.|:
  Rat   357 FSFPGSGGLCTLVMAFLAGMRWTDKK-------------SEVEKIIALTWDVFQPLLFGLIGAEV 408

  Fly   575 NFNVLQGHVIGYGALLVLVGSLFRLAFAYLSTYGGNLSRKERAYITISGFPKATVQAALGPVALD 639
            :...|:...:|.....:.:..|.|:...:|.......:.||:.:|:.:..||||||||:|.||||
  Rat   409 SIASLRAETVGLCVATLGIAVLIRILTTFLMVCFAGFNIKEKIFISFAWLPKATVQAAIGSVALD 473

  Fly   640 MARAASVASPEQLALAGNLLIISVLAIIFTAPLGAILMLRLAPYWLKHGD 689
            .||:......|...:  ::|.::.|||:.|||:|::|:..|.|..|:..:
  Rat   474 TARSHGEKQLEDYGM--DVLTVAFLAILITAPIGSLLIGLLGPRVLQKSE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	140/414 (34%)
Slc9b2	NP_001102855.1	Na_H_Exchanger	176..534	CDD:294713	124/361 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340821
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D406317at33208
OrthoFinder	1	1.000	-	-		FOG0001578
OrthoInspector	1	1.000	-	-		mtm8970
orthoMCL	1	0.900	-	-		OOG6_103025
Panther	1	1.100	-	-	O	PTHR31102
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.710