DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nha2 and SLC9A5

DIOPT Version :9

Sequence 1:	NP_001247251.1	Gene:	Nha2 / 42710	FlyBaseID:	FBgn0263390	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_004585.1	Gene:	SLC9A5 / 6553	HGNCID:	11078	Length:	896	Species:	Homo sapiens

Alignment Length:	519	Identity:	104/519 - (20%)
Similarity:	187/519 - (36%)	Gaps:	143/519 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 TPGDEYKGP---KW-WLYIRSHWVNTSELVALLAIFLGLWAMGWVLLPEYSQPPTVIMRIAFLFV 284
            :||:...|.   :| |     |.|....||||           |:|:..       :.:|.| .:
Human    26 SPGEPPPGLELFRWQW-----HEVEAPYLVAL-----------WILVAS-------LAKIVF-HL 66

  Fly   285 GAQISGILVTFVHLPD-----MLGMLFFGVLYANLGLANFEGYQ----KFELFLREMALINIMLL 340
            ..:::.:      :|:     :||::..|::   |.:|....||    .|.|||    |..|:|.
Human    67 SRKVTSL------VPESCLLILLGLVLGGIV---LAVAKKAEYQLEPGTFFLFL----LPPIVLD 118

  Fly   341 AGLGLDGDAFKRLWFMILRLTL--LPTIVEVAAIAGLANLTLSMPWLWG---------------- 387
            :|           :||..||..  |..|:..|.:..|.|...:...|||
Human   119 SG-----------YFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAGLL 172

  Fly   388 --IALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGVIISVIFSTT 450
              :..|.:|:||.|..|:.|.     :.:.:|..:..:::..:..||.|.:.::.|..|.:...:
Human   173 DFLLFGSLISAVDPVAVLAVF-----EEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGS 232

  Fly   451 SLTQ--QVLQGPI--------GIGIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVM 505
            :..|  ..|:|..        |..:||||.:|.....:: ..|.......|.|:|.......|.|
Human   233 ANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRF-TKRVRIIEPLLVFLLAYAAYLTAEM 296

  Fly   506 G--SRVIGYTSAGALGCVTTAFIARIGWRREETRLTPQQLQAQQIASVPKRLDLMWKFLKPVSFA 568
            .  |.::..|..| |||               .:.....:..:...:|...:..:....:.|.|.
Human   297 ASLSAILAVTMCG-LGC---------------KKYVEANISHKSRTTVKYTMKTLASCAETVIFM 345

  Fly   569 LIGKEINFNVLQGHVIGYGALLVLVGSL-----FRLAFAYLSTYGGN------LSRKERAYITIS 622
            |:|    .:.:......:.:.||| |:|     ||.....|.|:..|      |.:.::..::..
Human   346 LLG----ISAVDSSKWAWDSGLVL-GTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYG 405

  Fly   623 GFPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIFTAPLGAILMLRLAPYWLK 686
            |...|...|.:  :.||..:..          |.:..:.:.:.::|...:...|.::....|||
Human   406 GLRGAVAFALV--ILLDRTKVP----------AKDYFVATTIVVVFFTVIVQGLTIKPLVKWLK 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	89/458 (19%)
SLC9A5	NP_004585.1	NhaP2	41..630	CDD:330436	100/504 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..686
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..864
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900