Protein Alignment Nha2 and SLC9A3

DIOPT Version :9

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_004165.2
• Gene: SLC9A3 / 6550
• HGNCID: 11073
• Length: 834
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 103/536 - (19%)
• Similarity: 185/536 - (34%)
• Gaps: 149/536 - (27%)

  Fly   235 WLYIRSHWVNTSELVALLAIFLGLWAMGWVLLPEYSQPPTVIMRIAFLFVGAQISGILVTFVHLP 299
            |.:::..:|     :||..:...|..:|:.|..:.:   :|:...|.|.|
Human    49 WAHVQDPYV-----IALWILVASLAKIGFHLSHKVT---SVVPESALLIV--------------- 90

  Fly   300 DMLGMLFFGVLYANLGLANFEGYQKFELFLREMALINIMLLAGLGLDGDAF--KRLWFMILRLTL 362
              ||::..|:::|...:|:|........|         .||..:.||...|  .||:|..|...|
Human    91 --LGLVLGGIVWAADHIASFTLTPTVFFF---------YLLPPIVLDAGYFMPNRLFFGNLGTIL 144

  Fly   363 LPTIVEV---AAIAGLANLTLSMPWLWG---------IALGLVITAVSPNVVVTVMLKLKEDRLG 415
            |..:|..   ||..||:...:.:..|.|         :..|.::.||.|..|:.|.     :.:.
Human   145 LYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVF-----EEVH 204

  Fly   416 LNSGIHTLIYAMTTCNDVVAIFMFGVIIS------------------VIFSTTSLTQQVLQGPIG 462
            :|..:..:::..:..||.|.:.::.|..|                  |.|...||.        |
Human   205 VNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLG--------G 261

  Fly   463 IGIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVM--GSRVIGYTSAGALGCVTTAF 525
            ..:|:||.:|. |::............|..|:::.|....:.|  .|.::..|..|.  |.....
Human   262 TLVGVVFAFLL-SLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGI--CCQKYV 323

  Fly   526 IARIGWRREETRLTPQQLQAQQIASVPKRLDLMWKFLKPV---------SFALIGKEINFNVLQG 581
            .|.|    .|...|..:...:.:||..:.:..|:..:..|         :|.|:
Human   324 KANI----SEQSATTVRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLL----------- 373

  Fly   582 HVIGYGALLVLVGSLFRLAFAYLSTYGGNLSRK------ERAYITISGFPKATVQAALGPVALDM 640
                   .||.: |::|.....|.|:..|..|.      ::..::..|...|...|.:  |.||.
Human   374 -------TLVFI-SVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALV--VLLDG 428

  Fly   641 ARAASVASPEQLALAGNLLIISVLAIIFTAPLGAILMLRLAPYWLK---------------HGDA 690
            .:...          .||.:.:.:.::|...:...|.::....|||               ||.|
Human   429 DKVKE----------KNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRA 483

  Fly   691 VEAVDSPTTPIAPTLG 706
            .:.:.|....|:..:|
Human   484 FDHILSAIEDISGQIG 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	87/455 (19%)
SLC9A3	NP_004165.2	b_cpa1	48..646	CDD:273294	103/536 (19%)
		Na_H_Exchanger	105..462	CDD:279355	79/416 (19%)
		Interaction with PDZD3. /evidence=ECO:0000250	590..667
		NEXCaM_BD	604..676	CDD:293250
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	679..728
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	814..834

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900