Protein Alignment Nha2 and slc9a5

DIOPT Version :10

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_001106943.1
• Gene: slc9a5 / 565213
• ZFINID: ZDB-GENE-080225-43
• Length: 970
• Species: Danio rerio
• Alignment Length: 518
• Identity: 104/518 - (20%)
• Similarity: 176/518 - (33%)
• Gaps: 191/518 - (36%)

  Fly   210 YG-PG-----SVSGYPTPNATPGDE-------YKGPKW-WLYIRSHWVNTSELV----------- 249
            || ||     |.....||:...|:.       :|..:| |.|:::.::..|.|:
Zfish    52 YGHPGIALARSAEEPTTPSTEDGESSHHHGGGFKIVQWEWSYVQTPYIIASWLLVASVAKILFHF 116

  Fly   250 ----------ALLAIFLGLWAMGW-VLLPEYSQPPTVIMRIAFLFVGAQISGILVTFVHLPDMLG 303
                      :.:.|.||| |:|. |||....||..:...:.|||:...|.|....|     |..
Zfish   117 SQRFTTAVPESCMLILLGL-ALGTVVLLASKKQPYQLDPGLFFLFLLPTIVGDAGYF-----MPA 175

  Fly   304 MLFFGVLYANLGLANFEGYQKFELFLREMALINIMLLAGLGLDGDAFKRLWFMILRLTLLPTIVE 368
            .|||.    |||.                    |::.|.:|...:||  .....|....:..:::
Zfish   176 RLFFD----NLGA--------------------ILMYAVVGTLWNAF--CTGFCLYGVKMAGVID 214

  Fly   369 VAAIAGLANLTLSMPWLWGIALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDV 433
            ....|||....|         .|.:|:||.|..|:.|.     :.:.:|..:..:::..:..||.
Zfish   215 EKVDAGLMEFLL---------FGALISAVDPVAVLAVF-----EEVHVNETLFIIVFGESLLNDA 265

  Fly   434 VAIFMFGVIISVIFSTTSLTQQVLQGPIGIGIGLVFGYLYGSMLQYLPSRNATYANGL-RFVLTI 497
            |.:.::.|.||.               :.:|.|.|              ..|.|..|: .|::..
Zfish   266 VTVVLYKVYISF---------------VEVGPGNV--------------NTADYFKGIASFLIVS 301

  Fly   498 LGGTIAVMGSRVIGYTSAGALGCVTTAFIARIGWRREETRLTPQQLQAQQIASVPKRLDLMWKFL 562
            :|||:            .|.:..|..||.         ||.|             |::    :.:
Zfish   302 IGGTL------------VGLIFAVILAFF---------TRFT-------------KKV----RII 328

  Fly   563 KPV-SFALIGKEINFNVLQGHVIGYGALLVLVGSLFRLAFAYLSTYGG---------NLSRKERA 617
            :|: .|.|:                 .|..|...||.|:.....|:.|         |:|:|.|.
Zfish   329 EPMFIFLLV-----------------YLAYLTAELFSLSAILSLTFCGIGCNKYVEANISQKSRT 376

  Fly   618 YI-----TISGFPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIFTAPLGAI 675
            .:     |::...:..:...||..|:|.::         .|....|::.:::.|:....:|.|
Zfish   377 TVKYTMKTLASIAETIIFIFLGISAVDKSK---------WAWDTGLVVSTLIFILVFRAMGVI 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	NhaP	279..>686	CDD:439796	79/413 (19%)
slc9a5	NP_001106943.1	Na_H_Exchanger	90..675	CDD:470090	94/480 (20%)