DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nha2 and slc9a2

DIOPT Version :9

Sequence 1:	NP_001247251.1	Gene:	Nha2 / 42710	FlyBaseID:	FBgn0263390	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001107567.1	Gene:	slc9a2 / 562904	ZFINID:	ZDB-GENE-070912-541	Length:	746	Species:	Danio rerio

Alignment Length:	412	Identity:	83/412 - (20%)
Similarity:	150/412 - (36%)	Gaps:	123/412 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 WVNTSELVALLAIFLGLWAMGWVLLPEYSQPPTVI-MRIAFLFVGAQISGILVTFVHLPDMLGML 305
            ||..|    .|.|.|| :.:|.|:.....:||.|| ..:.||::...|  ||.:...:|..
Zfish    53 WVPES----CLLISLG-FVVGGVMHAVRKEPPAVISSNVFFLYMLPPI--ILESGYFMPTR---- 106

  Fly   306 FFGVLYANLGLANFEGYQKFELFLREMALINIMLLAGLGLDGDAFKRLW-FMILRLTLLPTIVEV 369
               ..:.|:|                    .:|..|.:|       .|| .|.:.::|. .|.::
Zfish   107 ---PFFENVG--------------------TVMWFAVVG-------TLWNTMGIGISLF-AICQI 140

  Fly   370 AAIAGLANLTLSMPWLWGIALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVV 434
            .|. |:.::.|..    .:....:::||.|..|::|.    || :.:|..::.:::.....||.|
Zfish   141 EAF-GVQDINLQE----NLLFAAILSAVEPVAVLSVF----ED-ISINEQLYIVMFGECLFNDAV 195

  Fly   435 AIFMFGVI----------ISVIFSTTSLTQQVLQG--PIGIGIGLVFGYLYGSMLQYLPSRNATY 487
            .:.::.:.          .:|||..       :.|  .:|:| |:.||.|:|    :|.:....:
Zfish   196 TVVLYNLFNHVAAMEVDEPAVIFMD-------IGGFFVVGLG-GIFFGLLFG----FLTAFTTRF 248

  Fly   488 ANGLR-------FVLTILGGTIAVMGSRVIGYTSAGALGCVTTAFIARIGWRREETRLTPQQLQA 545
            ...:|       |:.:.:...||    .:...:|..|:...|.:....:.....:...|..:...
Zfish   249 TGKVREIEPLVIFMFSYMSYLIA----ELFALSSIMAILICTLSMKYYVEENVSQRSCTTIRHVI 309

  Fly   546 QQIASVPKRL---------------------------DLMWKFLKPVSFALI---GKEINFNVLQ 580
            :.:.||.:.|                           .|.|:||..:....|   .::|.||...
Zfish   310 KMVGSVSETLIFFFLGVVSITTEHEWNWGYILFTLFFTLFWRFLGILVLTQIINPFRKIPFNFQD 374

  Fly   581 GHVIGYGALLVLVGSL-FRLAF 601
            ...:.||.|.   |:| |.|||
Zfish   375 QFGLAYGGLR---GALSFALAF 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	70/374 (19%)
slc9a2	NP_001107567.1	b_cpa1	21..578	CDD:273294	83/412 (20%)
		Na_H_Exchanger	30..429	CDD:279355	83/412 (20%)
		NEXCaM_BD	525..629	CDD:293250
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900