DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nha2 and slc9a6b

DIOPT Version :9

Sequence 1:	NP_001247251.1	Gene:	Nha2 / 42710	FlyBaseID:	FBgn0263390	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001106947.1	Gene:	slc9a6b / 556638	ZFINID:	ZDB-GENE-080226-2	Length:	692	Species:	Danio rerio

Alignment Length:	545	Identity:	102/545 - (18%)
Similarity:	185/545 - (33%)	Gaps:	143/545 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 WLY--IRSHWVNTSELVALLAIFLGLWAMGWVLLPE-----------YSQPPTVIMRIAFLFVGA 286
            ||:  .|..:::.:.|..:..:|:|:.....|..|:           .|.|.|:::.::..|...
Zfish    71 WLFKHRRFRFLHETGLAMIYGLFVGVILRFGVHSPQDTSEVTLSCAVNSSPTTILVNVSGRFYEY 135

  Fly   287 QISGIL----------------VTFVHLPDMLGMLFFGVLYANLGLANFEGYQ-KFELFLREMAL 334
            .:.|.:                |||.  |:    :||.:|..  .:....||. |...|.|.:.
Zfish   136 SLKGEVQDSKGHDVPNAEMLRKVTFD--PE----VFFNILLP--PIIFHAGYSLKRRHFFRNLG- 191

  Fly   335 INIMLLAGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIAGLANLTLSMPWLWGIALGLVITAVSP 399
             :|:..|.:|.....|      :..|.:...:|.:..|..|.........|:   .|.:::|..|
Zfish   192 -SILSYAFVGTMTSCF------VTGLAMYSCVVFMKIIGQLGGDFFFTDCLF---FGAIVSATDP 246

  Fly   400 NVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGVIISV--------IFSTTSLTQQV 456
            ..|:.:..:||.|     ..::.|::..:..||.|||.:...|::.        .|..::|.:
Zfish   247 VTVLAIFNELKVD-----VDLYALMFGESVLNDAVAIVLSSSIVAYQPEGDNRHTFDASALLK-- 304

  Fly   457 LQGPIGIGIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVMGSRVIGYTSAGALGCV 521
                   .:|:..|...||.                    .:|....||.:.|..:|.......:
Zfish   305 -------CLGVFLGVFSGSF--------------------AMGAATGVMTALVTKFTKLRDFPLL 342

  Fly   522 TTAFIARIGWRR--------------------EETRLTPQQLQAQQIASVPKRLDLMWKFLKPVS 566
            .||....:.|..                    .:...|...|..:..:...:..:|:....:...
Zfish   343 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESKSRTKQLFELLNFLAENFI 407

  Fly   567 FALIGKEINFNVLQGHVIG----YGALLVLVGSLFRLAFAYLSTYGGNLSRKERA------YITI 621
            |:.:|  :.....|.||..    .||.:.:.  |.|||..|..::..||.||.:.      .:..
Zfish   408 FSYMG--LTLFSFQHHVFNPFFIIGAFVAIF--LGRLANIYPLSFLLNLGRKNKIPSNFQHVMMF 468

  Fly   622 SGFPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIF---TAPLGAILMLRLAPY 683
            ||...|..      .||.:...|:.|  .|:..:..|||:.....:.   |.|:.:::.:|:
Zfish   469 SGLRGAMT------FALSIRDTATYA--RQMMFSTTLLIVFFTVWVCGGGTTPVLSLMQIRV--- 522

  Fly   684 WLKHGDAVEAVDSPTTPIAPTLGST 708
                |...|..:|.|.....|..||
Zfish   523 ----GVDTEQDNSATAADGMTQRST 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	84/464 (18%)
slc9a6b	NP_001106947.1	Na_H_Exchanger	158..515	CDD:279355	81/421 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900