Protein Alignment Nha2 and slc9a6b

DIOPT Version :10

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_001106947.1
• Gene: slc9a6b / 556638
• ZFINID: ZDB-GENE-080226-2
• Length: 692
• Species: Danio rerio
• Alignment Length: 545
• Identity: 102/545 - (18%)
• Similarity: 185/545 - (33%)
• Gaps: 143/545 - (26%)

  Fly   235 WLY--IRSHWVNTSELVALLAIFLGLWAMGWVLLPE-----------YSQPPTVIMRIAFLFVGA 286
            ||:  .|..:::.:.|..:..:|:|:.....|..|:           .|.|.|:::.::..|...
Zfish    71 WLFKHRRFRFLHETGLAMIYGLFVGVILRFGVHSPQDTSEVTLSCAVNSSPTTILVNVSGRFYEY 135

  Fly   287 QISGIL----------------VTFVHLPDMLGMLFFGVLYANLGLANFEGYQ-KFELFLREMAL 334
            .:.|.:                |||.  |:    :||.:|..  .:....||. |...|.|.:.
Zfish   136 SLKGEVQDSKGHDVPNAEMLRKVTFD--PE----VFFNILLP--PIIFHAGYSLKRRHFFRNLG- 191

  Fly   335 INIMLLAGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIAGLANLTLSMPWLWGIALGLVITAVSP 399
             :|:..|.:|.....|      :..|.:...:|.:..|..|.........|:   .|.:::|..|
Zfish   192 -SILSYAFVGTMTSCF------VTGLAMYSCVVFMKIIGQLGGDFFFTDCLF---FGAIVSATDP 246

  Fly   400 NVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGVIISV--------IFSTTSLTQQV 456
            ..|:.:..:||.|     ..::.|::..:..||.|||.:...|::.        .|..::|.:
Zfish   247 VTVLAIFNELKVD-----VDLYALMFGESVLNDAVAIVLSSSIVAYQPEGDNRHTFDASALLK-- 304

  Fly   457 LQGPIGIGIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVMGSRVIGYTSAGALGCV 521
                   .:|:..|...||.                    .:|....||.:.|..:|.......:
Zfish   305 -------CLGVFLGVFSGSF--------------------AMGAATGVMTALVTKFTKLRDFPLL 342

  Fly   522 TTAFIARIGWRR--------------------EETRLTPQQLQAQQIASVPKRLDLMWKFLKPVS 566
            .||....:.|..                    .:...|...|..:..:...:..:|:....:...
Zfish   343 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESKSRTKQLFELLNFLAENFI 407

  Fly   567 FALIGKEINFNVLQGHVIG----YGALLVLVGSLFRLAFAYLSTYGGNLSRKERA------YITI 621
            |:.:|  :.....|.||..    .||.:.:.  |.|||..|..::..||.||.:.      .:..
Zfish   408 FSYMG--LTLFSFQHHVFNPFFIIGAFVAIF--LGRLANIYPLSFLLNLGRKNKIPSNFQHVMMF 468

  Fly   622 SGFPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIF---TAPLGAILMLRLAPY 683
            ||...|..      .||.:...|:.|  .|:..:..|||:.....:.   |.|:.:::.:|:
Zfish   469 SGLRGAMT------FALSIRDTATYA--RQMMFSTTLLIVFFTVWVCGGGTTPVLSLMQIRV--- 522

  Fly   684 WLKHGDAVEAVDSPTTPIAPTLGST 708
                |...|..:|.|.....|..||
Zfish   523 ----GVDTEQDNSATAADGMTQRST 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	NhaP	279..>686	CDD:439796	84/464 (18%)
slc9a6b	NP_001106947.1	Na_H_Exchanger	75..567	CDD:470090	100/541 (18%)