Protein Alignment Nha2 and SLC9A4

DIOPT Version :9

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_001011552.2
• Gene: SLC9A4 / 389015
• HGNCID: 11077
• Length: 798
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 98/472 - (20%)
• Similarity: 168/472 - (35%)
• Gaps: 152/472 - (32%)

  Fly   252 LAIFLGLWAMGWVLLPEYSQPPTVIMRIAFLFVGAQISGILVTFVHLP-----DMLGMLFFGVLY 311
            |.|.:|....|.:...::..||.:...|.||::...|  :|.....:|     :.:|.:.:   :
Human   102 LLILVGALVGGIIFGTDHKSPPVMDSSIYFLYLLPPI--VLEGGYFMPTRPFFENIGSILW---W 161

  Fly   312 ANLGLANFEGYQKFELFLREMALINIMLLAGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIAGLA 376
            |.||                 ||||.:   |:||.                |..|.:|.|. ||.
Human   162 AVLG-----------------ALINAL---GIGLS----------------LYLICQVKAF-GLG 189

  Fly   377 NLTLSMPWLWGIALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGV 441
            ::.|    |..:..|.:|:||.|   |.|:...:|.|  :|..::.:|:.....||.:.:.::.:
Human   190 DVNL----LQNLLFGSLISAVDP---VAVLAVFEEAR--VNEQLYMMIFGEALLNDGITVVLYNM 245

  Fly   442 IISVIFSTTSL-------TQQVLQG-----PIGIG---IGLVFGYLYGSMLQYLPSRNA------ 485
            :|:.    |.:       |..:|.|     .:|:|   .|:|||::...:.::..:.:|
Human   246 LIAF----TKMHKFEDIETVDILAGCARFIVVGLGGVLFGIVFGFISAFITRFTQNISAIEPLIV 306

  Fly   486 ---TYANGLRFVLTILGGTIAVMGSRV------------------------------------IG 511
               :|.:.|......|.|.:|:....|                                    :|
Human   307 FMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMG 371

  Fly   512 YTSAG-------ALGCVTTAFIARIGWR----------REETRLTPQQLQAQQI---ASVPKRLD 556
            .::.|       |..|.|.|| .:| ||          ..:.|..|..::.|.|   :.|.....
Human   372 VSTVGKNHEWNWAFICFTLAF-CQI-WRAISVFALFYISNQFRTFPFSIKDQCIIFYSGVRGAGS 434

  Fly   557 LMWKFLKPVSFALIGKEINFNVLQGHVIGYGALL--VLVGSLFRLAFAYLSTYGGNL--SRKERA 617
            ....||.|:|  |..::..|......||.:...:  :.||.|.|    ||.....|.  |..|..
Human   435 FSLAFLLPLS--LFPRKKMFVTATLVVIYFTVFIQGITVGPLVR----YLDVKKTNKKESINEEL 493

  Fly   618 YITISGFPKATVQAALG 634
            :|.:....||.::...|
Human   494 HIRLMDHLKAGIEDVCG 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	92/445 (21%)
SLC9A4	NP_001011552.2	b_cpa1	63..621	CDD:273294	98/472 (21%)
		Na_H_Exchanger	73..476	CDD:279355	88/432 (20%)
		NEXCaM_BD	569..675	CDD:293250
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..690
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	776..798

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900